Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Sustainable energy from wind and solar is most readily available near the sea.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Promotie

Promotie

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Promotie

Promotor: Prof.dr. G.J. Kroes

Promotor: A.P. IJzerman

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

Promotie

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Hoe kan de methode om de gecombineerde effecten van metaal-gebaseerde chemische stoffetn te bepalen worden verbeterd?

NWO heeft Natuurkunde Vrije Programma’s toegekend aan vijf samenwerkingen tussen natuurkundigen aan verschillende universiteiten. De Universiteit Leiden is betrokken bij drie van deze vijf.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Congres/symposium

Promotie

De

Promotie

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