Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

De focus van dit proefschrift is het leren en de samenwerking van docenten in het voortgezet onderwijs.

Stimuleren van Prestaties en Motivatie in de Eerste Jaren van het Voortgezet Onderwijs

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Students with learning problems experience difficulties in reading, writing, and content-area learning into and throughout their secondary-school years

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

In deze studie wordt verslag gedaan van een onderzoek naar de ontwikkeling van de praktijkkennis bij elf docenten Nederlands. Zij ontwikkelden en implementeerden concept-contextrijk onderwijs met behulp van actieonderzoek.

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

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The World Teachers Programme is conducted in close cooperation with EP-Nuffic and partner schools.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

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Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

PUMA aims at composing a geological map of the urban mine of Amsterdam for a selection of metals. Where are main deposits of copper, iron and aluminium located, when will they become available for secondary production, in what state and shape are they?

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

What is vegetation structure and composition in SFM primary forest, secondary logged over forest (logging FSC certified and logging non certified) in comparison to primary forest? What is avian guild diversity in SFM primary forest, secondary logged over forest (logging FSC certified and logging non…

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Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

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This thesis describes the Multi-site All-Sky CAmeRA (MASCARA), which consists of two small robotic telescope designed to detect exoplanets around the brightest stars in the sky.

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

Op 9 juli openende het nieuwe Medical Delta Fieldlab Phenomix haar deuren. In het fieldlab werken wetenschappers, zorginstellingen en bedrijven samen praktische toepassingen van metabolomics-onderzoek: onderzoek naar stofwisselingsproducten. Medical Delta sprak met de Leidse hoogleraar Thomas Hankemeier.…

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In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…