Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Promotor: Prof.dr. H.S. Overkleeft

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

Promotor: T. Schmidt

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Existing work in probabilistic language modeling can be mostly divided into two categories: (i) Purely sequential, string-level approaches ensure fluency at the local level without notion of grammaticality and seek improvements in the use of massive training corpora. (ii) Fully structural, tree-based…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

De verhoogde activatie van het striatum, die adolescenten laten zien bij beloning, wordt meestal in verband gebracht met risicogedrag en negatieve gezondheidseffecten. In dit artikel in Nature Communications wordt een mogelijke positieve kant van die verhoogde activatie onderzocht. De activatiepiek…

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Het artikel 'Flexible updating of dynamic knowledge structures' met bijdrage van Franziska Richter van Cognitieve Psychologie is uitgebracht door Nature.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Promotor: Prof.dr. M. Danhof

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

Improvements of weak gravitational lensing shape measurements are presented and some used for data analysis.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

Promotor: Prof.dr. M. Ubbink

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Fokelien Kootstra verdedigde haar proefschrift op 23 april 2019

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Promotor: S.J. Edixhoven, A. Iovita

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

This thesis consists of three papers that are centered around the common theme of Hausdorff uo-Lebesgue topologies and convergence structures on vector lattices and on vector lattices and vector lattice algebras of order bounded operators.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotor: K.H. Kuijken

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Wetenschappers bij de Leidse Sterrewacht onderzoeken de fundamenteel natuurkundige verschijnselen die voor structuur in het heelal zorgen. Deze processen brengen materie bijeen tot sterrenstelsels en gas bijeen tot sterren. Met behulp van krachtige telescopen en geavanceerde berekeningen en computersimulaties…

Overkleeft

Quantifying physical activity (using accelerometers) and combining the frequency and intensity of activities with health data (brain MRI, traditional clinical parameters and metabolomics) is of utmost importance to monitor mobility and health among older individuals and study health promotion during…

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

Curved single crystals provide variable, but well-defined surface structures.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver