Wiskunde en Natuurwetenschappen, Sterrewacht Leiden (STRW)

Where and how are critical materials currently used and how can this information be used to develop scenarios about their future demand.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

How can we quantify the density of species within a community through environmental DNA concentrations?

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Promotor: B.van de Water, Co-promotor: L.S.Price

Hetterscheid

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Promotores: B. Erez, P. Stevenhagen, Co-Promotor: B. de Smit

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

Op 29 april 2020 verdedigde Beth Van Schaack haar proefschrift 'Imagining Justice for Syria: Water Always Finds Its Way'. Het promotieonderzoek is begeleid door promotor prof.dr. C. Stahn.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Promotor: Prof.dr. J. Kuiper

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Promotor: Prof.dr. P. Stevenhagen

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

Het ontwikkelen van nieuwe medicijnen is een complex proces waarbij veel partijen samenwerken. De onderzoekers van het LACDR zetten zich dagelijks in voor nieuwe, betere, efficiëntere en makkelijker produceerbare medicijnen. Het instituut werkt nauw samen met het LUMC, met bedrijven op het Leiden Bio-Science…

Het artikel gaat over de fysiologische herkenning van daderkennis en of dit ook gebruikt van worden om ware van valse bekentenissen te onderscheiden.

Het centrale doel van dit proefschrift is inzicht verschaffen in hoe de implementatie van een peer educator-interventie van invloed kan zijn op de houding van leerlingen tegenover LHBT-leeftijdgenoten en op de relatie tussen deze houdingen en reflectie over burgerschap.

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Het doel van dit proefschrift is om eerst te onderzoeken welke vormen van samenwerkend leren bij de verschillende conservatoria in de praktijk worden gebracht, om vervolgens te kijken naar hoe samenwerkend leren kan worden geïmplementeerd.

Het BENEFIT-programma is een publiek-privaat ecosysteem in een nationaal consortium, met als doel patiënten met cardiovasculaire aandoeningen langdurig in hun eigen thuissituatie te ondersteunen bij een gezonde leefstijl.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Op 17 december 2018 verdedigde Dejian Kong zijn proefschrift 'Civil Liability for Damage caused by Global Navigation Satellite System'. Het promotieonderzoek is begeleid door promotor prof. dr. P.M.J. Mendes de Leon.

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.