12 zoekresultaten voor “proteasome” in de Publieke website
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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The use of activity based protein profiling to study proteasome biology
Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea
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Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Promotie
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Chemical tools to monitor and control human proteasome activities
Promotie
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The Use of Activity-Based Protein Profiling to Study Proteasome Biology
Promotie
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Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
Promotie
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Leidse chemici brengen afvalverwerkingsfabriek van de cel in kaart
Om de werking van anti-kankermedicijn Bortezomib te begrijpen brengen Leidse chemici de machinerie van het proteosoom in kaart. Dit is de afvalverwerkingscentrale van de cel. Ze delen hun methode in Nature Protocols zodat labs ermee aan de slag kunnen.
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Chemische gereedschapkist in de strijd tegen kanker
Chemische stoffen maken, om biologische vragen mee op te lossen. Wouter van der Linden vat even kort de chemische biologie samen. Daaraan levert hij zijn bijdrage met stoffen die uiteindelijk behulpzaam zijn in de strijd tegen kanker: ‘Dus niet de medicijnen zelf, maar een chemische gereedschapskist…
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This Week’s Discoveries | 23 February 2016
Lezing