165 zoekresultaten voor “profiling” in de Publieke website

• Activity-Based Proteasome Profiling Onderzoeksoutput

  Promotor: Prof.dr. H.S. Overkleeft

• Inhibitor Selectivity: Profiling and Prediction Onderzoeksoutput

  Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

• Activity-based protein profiling in drug discovery Onderzoeksoutput

  In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

• Activity-based protein profiling of diacylglycerol lipases Onderzoeksoutput

  Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

• Cyclophellitol analogues for profiling of exo- and endo-glycosidases Onderzoeksoutput

  To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

• Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases Onderzoeksoutput

  Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

• High-throughput profiling of small molecules using mass spectrometry Onderzoeksoutput

  Promotor: Prof.dr. T. Hankemeier

• Activity-based protein profiling of glucosidases, fucosidases and glucuronidases Onderzoeksoutput

  Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

• Direct and two-step activity-based profiling of proteases and glycosidases Onderzoeksoutput

  Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

• Exploring and exploiting activity-based protein profiling in chemical biology and medicinal chemistry Onderzoeksproject

  Overkleeft

• The use of activity based protein profiling to study proteasome biology Onderzoeksoutput

  Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

• The quantification of growth hormone secretion : application of model-informed drug development in acromegaly Onderzoeksoutput

  Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

• 
  Casper de Boer Promovendus

  Wiskunde en Natuurwetenschappen

• Development of kinase inhibitors and activity-based probes Onderzoeksoutput

  Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

• 
  Hermen Overkleeft Wetenschappelijk directeur / hoogleraar Bio-organische synthese

  Wiskunde en Natuurwetenschappen

• 
  Bart Custers Hoogleraar Law and Data Science

  Faculteit Rechtsgeleerdheid

• 16S rRNA Gene Profiling Agenda - 8 december 2020

  Promotie

• Visualization of Vitamin A Metabolism Onderzoeksoutput

  Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

• Inhibitors and probes targeting endo-glycosidases Onderzoeksoutput

  The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

• Advancing forensic RNA profiling Agenda - 28 juni 2018

  Promotie

• Nano shapes micro : Impacts of metallic nanoparticles on microbial communities Onderzoeksoutput

  This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

• Design and development of conformational inhibitors and activity-based probes for retaining glycosidases Onderzoeksoutput

  Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

• Effect of Nanoparticles on Microbial Catabolism and Community Structure using Biolog techniques Onderzoeksproject

  1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

• Asian Modernities and Traditions Onderzoeksproject

  The research profile ‘Asian Modernities and Traditions’ (AMT) aims to raise the strength and visibility of research, teaching and dissemination of Asian studies at Leiden University.

• Omics profiling of cardiometabolic diseases Agenda - 26 mei 2020

  Promotie

• Mass spectrometry based protein profiling Agenda - 31 augustus 2016

  Promotie

• Mass spectrometry based protein profiling Agenda - 14 april 2016

  Promotie

• CONSENT Onderzoeksproject

  CONSENT (Consumer sentiment regarding privacy on user generated content services in the digital economy) is a research project funded by the European Union under the 7th Framework Programme. The question central to this research is whether recent changes to consumer and commercial practices developed…

• Inhibitor Selectivity: Profiling and Prediction Agenda - 1 mei 2019

  Promotie

• Activity-based proteomics of the endocannabinoid system Onderzoeksoutput

  This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

• The evolution of chemical diversity in plants : pyrrolizidine alkaloids and cytochrome P450s in Jacobaea Onderzoeksoutput

  Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

• Non-target effects of GM potato: an eco-metabolomics approach Onderzoeksoutput

  Promotores: P.G.L. Klinkhamer, P.M. Brakefield, Co-Promotor: M. Bruinsma

• Activity-based protein profiling and bio-orthogonal chemistry Agenda - 19 april 2017

  Congres/symposium

• Activity-based Protein Profiling of the Diacylglycerol Lipases Agenda - 6 april 2017

  Promotie

• Prevalence, symptoms and risk profiles of apathy at old age Agenda - 7 november 2017

  Promotie

• Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases Agenda - 8 april 2020

  Promotie

• New insights in the risk profile for arterial thrombosis Agenda - 21 november 2017

  Promotie

• Cyclophellitol analogues for profiling of exo- and endo-glycosidases Agenda - 17 mei 2018

  Promotie

• Activity-based protein profiling in drug discovery Agenda - 28 mei 2019

  Promotie

• Activity-based protein profiling of glucosidases, fucosidases and glucuronidases Agenda - 23 juni 2016

  Promotie

• Development of automatic image analysis methods for high-throughput and high-content screening Onderzoeksoutput

  Promotor: Prof.dr. B. van de Water

• Chemical tools to study lipid signaling Onderzoeksoutput

  Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

• The evolution of shell form in tropical terrestrial microsnails Onderzoeksoutput

  Promotor: Prof.dr. M. Schilthuizen

• Prediction of spatial-temporal brain drug distribution with a novel mathematical model Onderzoeksoutput

  A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

• CE-MS for metabolomics: advancing performance and detection sensitivity Onderzoeksoutput

  The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

• Biodiesel production using blue-green cyanobacterium Synechococcus elongatus PCC 7942 Onderzoeksoutput

  Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

• The Use of Activity-Based Protein Profiling to Study Proteasome Biology Agenda - 11 februari 2016

• Working Paper-serie eLaw - Centrum voor Recht en Digitale Technologie

  In de eLaw Working Paper-serie kunnen onderzoekers van eLaw de onbewerkte versies van manuscripten plaatsen die zijn geaccepteerd voor publicatie door tijdschriften en boeken.

• Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs Onderzoeksoutput

  Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

• Determining the most appropriate dose metrics for evaluating dose-response relationships of metal-based nanoparticles to Zebrafish embryos Onderzoeksoutput

  Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver