Promotores: H.W. Lenstra, A. Lucchini

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

Promotor: Prof.dr. P. Stevenhagen, Co-Promotor: J.H. Evertse

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Assuming everywhere good reduction we generalize the class number formula of Taelman to Drinfeld modules over arbitrary coefficient rings.

How are links between macro-invertebrate diversity and ecosystem functioning influenced by anthropogenic pressures?

Het onderzoek in dit proefschrift kijkt naar de rol van het locus ceuruleus - noradrenalinesysteem in verscheidene aspecten van menselijke cognitie, en de modulatie van de staat van het brein.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

What are trait-trait relationships in wetlands? To what extent the so-called leaf economics traits deviate from terrestrial ecosystems? How traits specific to wetland plant relate to plant strategies? What’s the relationship between wetland plant traits to the ecosystem functioning (e.g. productivity,…

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

In dit onderzoek wordt hersenontwikkeling voor het eerst direct gelinkt aan sekseverschillen en schoolprestatie. De resultaten ontkrachten de mythe dat jongens achterlopen in hersenontwikkeling.

Het terugdringen van agressie is in de afgelopen jaren in toenemende mate een maatschappelijke prioriteit geworden. Agressie in de vroege kindertijd vergroot de kans op latere agressieproblemen en antisociaal gedrag.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Op 7 november 2018 verdedigde Catherine Harwood haar proefschrift 'Navigating Between Principle and Pragmatism: The Roles and Functions of Atrocity-Related United Nations Commissions of Inquiry in the International Legal Order'. Het promotieonderzoek is begeleid door promotoren prof. dr. L.J. Van den…

In Nederland komt gehoorverlies voor bij 1 tot 2 op de 1000 kinderen. In ongeveer een kwart van de gevallen is de oorzaak niet bekend. De mate van gehoorverlies kent een grote variatie. In dit proefschrift worden kinderen besproken met een gehoorverlies variërend van matig (40 dB, te vergelijken met…

Promotie

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Promotie

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

In this thesis three different topics in number theory are studied.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Promotor: A.P. IJzerman

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

1: What is the relative importance of alfa and beta biodiversity in polar ecosystems, and how does intraspecific variation influence this? 2: How can we use remote sensing to determine functional biodiversity (within communities) in polar ecosystems? 3: Temporal and spatial scales of functional biodiversity:…

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Promotor: W. T. F. den Hollander, F. H. J. Redig

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Possible improvements for the assessment of abiotic depletion in LCA.

Promotie