M. Danhof, Co-promotores: J. Freijer, A. Yassen

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Promotie

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Congres/symposium

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development:…

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

The logic seems inescapable indeed. The bigger the population, the higher the probability it contains an Einstein. Hence, bigger populations are more likely to develop complex culture.

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

Promotor: Roeland M.H. Merks

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Promotor: Prof.dr. E. Deprettere

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Promotor: B.van de Water, Co-promotor: L.S.Price

Promotor: Prof.dr. J.N. Kok

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Promotor: Prof.dr. B.R. Katzy

... which builds on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Promotores: J. Kok, M. Chaudron (Chalmers University)

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Promotores: G.R. de Snoo, B. Sinsin, Co-Promotor: H.H. de Iongh

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

What is the population size and social structure in time and space? What is the lion diet and food preference in time and space? What is the home range (MCP and Kernel) and movement in time and space? What are human – lion conflict and responses of lions to traditional herding in time and space? What…

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Promotor: Prof.dr. A.G.G.M. Tielens

Komen medicijnen in de juiste hoeveelheid aan op de juiste plek in ons brein? Door een model te maken dat ons brein in kleine ‘hersenblokjes’ weergeeft, probeert promovenda Esmée Vendel hier een antwoord op te vinden. Haar nieuwe, wiskundig model voorspelt de medicijnconcentratie in de hersenen over…

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

Bij het programmeren van nieuwe features in software worden makkelijk veel fouten gemaakt. Hierdoor ontstaan bugs, die ertoe leiden dat software later op de markt komt en duurder is. Michiel Helvensteijn, promovendus van CWI en het Leiden Institute of Advanced Computer Science, onderzocht manieren om…