32 zoekresultaten voor “pharmacokinetics” in de Publieke website
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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The impact of obesity on the pharmacokinetics of drugs in adolescents and adults
Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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ics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Pharmacology based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Hersenonderzoek doen alsof je Mastermind speelt
De hersenen zijn een complex weefsel, en onderzoek doen naar medicijnen voor hersenaandoeningen is zo mogelijk nog complexer. Elizabeth (Liesbeth) de Lange, hoogleraar Voorspellende Farmacologie, pleit voor een zeer gestructureerde aanpak. ‘Het is eigenlijk net als Mastermind spelen.’ Oratie op 22 m…
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Weinig bewijs dat doping écht werkt
De lijst met verboden middelen van het Wereld Anti-Doping Agentschap (WADA) is enorm. Promovendus Jules Heuberger nam een groot deel ervan onder de loep, net als de detectiemethoden. Hij concludeerde: er is voor maar weinig stoffen bewijs dat ze daadwerkelijk de prestatie bevorderen. Promotie op 16…
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amic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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The quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Aan de wieg van farmacologische modellen
Na 41 jaar neemt Meindert Danhof, hoogleraar Farmacologie, op 31 maart afscheid van het Leiden Academic Centre for Drug Research. Een symposium ter ere van hem, voorafgaand aan het afscheidscollege, laat zien wat er in die periode bereikt is. Danhof kijkt met plezier terug.
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Mastermind spelen om Alzheimer te ontrafelen
Om het ziekteverloop van de Ziekte van Alzheimer beter te begrijpen, is volgens Frédérique Kok een strategische en gestructureerde aanpak nodig: de Mastermindmethode. Met haar LUF-subsidie wil Kok data van hoge kwaliteit verzamelen om een wiskundig model maken dat het ontstaan van de ziekte kan herkennen…
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Population Pharmacokinetic and Pharmacodynamic Analysis in Anesthesia
Promotie
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Promotie
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studies in special populations: towards semi-physiological pharmacokinetic models
Promotie
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Afscheidssymposium Prof. dr. M. Danhof: "Four decades of Research in Pharmacokinetics, Pharmacodynamics and beyond...",
Congres/symposium
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The impact of obesity on the pharmacokinetics of drugs in adolescents and adults
Promotie
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ics in zebrafish: integration of experimental and computational methods
Promotie
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amic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Promotie
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Pharmacogenomics in Drug Development: Implementation and Application of PKPD Model Based Approaches
Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development:…
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Comorbidities, complications and treatment of childhood obesity
Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.
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Research Achievement Award voor Meindert Danhof
Prof.dr. Meindert Danhof ontving op 15 november een Research Achievement Award in Pharmacokinetics, Pharmacodynamics & Drug Metabolism.
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Assistant professor in Pharmacology
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Eredoctor Elizabeth de Lange geëerd in Uppsala
Hoogleraar Elizabeth de Lange is op 31 januari geëerd door de Universiteit van Uppsala, die haar eind 2019 benoemde tot eredoctor. Tijdens de ceremonie ontving De Lange de drie symbolen van eer voor een eredoctoraat: een hoed, een diploma en een ring. ‘Een ongelofelijk prachtige ervaring!’
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Chemical approaches to control the in vivo behavior of nanomedicines
Lezing, Van Leeuwenhoek Lecture on BioScience