33 zoekresultaten voor “pharmacokinetics” in de Publieke website
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
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renal clearance in children using population pharmacokinetic and physiology based pharmacokinetic modeling approaches
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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clinical studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Pharmacology based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
Promotie
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Tamoxifen pharmacogenetics and pharmacokinetics in early-breast cancer
Promotie
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Pharmacogenomics in Drug Development: Implementation and Application of PKPD Model Based Approaches
Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …
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clinical studies in special populations: towards semi-physiological pharmacokinetic models
Promotie
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Promotie
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The impact of obesity on the pharmacokinetics of drugs in adolescents and adults
Promotie
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.
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Aan de wieg van farmacologische modellen
Na 41 jaar neemt Meindert Danhof, hoogleraar Farmacologie, op 31 maart afscheid van het Leiden Academic Centre for Drug Research. Een symposium ter ere van hem, voorafgaand aan het afscheidscollege, laat zien wat er in die periode bereikt is. Danhof kijkt met plezier terug.
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Hersenonderzoek doen alsof je Mastermind speelt
De hersenen zijn een complex weefsel, en onderzoek doen naar medicijnen voor hersenaandoeningen is zo mogelijk nog complexer. Elizabeth (Liesbeth) de Lange, hoogleraar Voorspellende Farmacologie, pleit voor een zeer gestructureerde aanpak. ‘Het is eigenlijk net als Mastermind spelen.’ Oratie op 22 m…
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PHD candidate, Mathematical modeling for prediction of liver toxicity
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Pharmaceutical Data Scientist (postdoc)
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Elke Krekels ontvangt Publicatieprijs Nederlandse Vereniging van Klinische Farmacologie
Krekels heeft zowel de Thesis Award als de TOP-Publicatieprijs ontvangen voor haar proefschrift ‘Size does matter: drug glucuronidation in children.’ Haar onderzoek leidde tot een nieuw doseervoorschrift van morfine voor baby’s en peuters. Beide prijzen werden uitgereikt tijdens de wetenschappelijke…
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Eredoctor Elizabeth de Lange geëerd in Uppsala
Hoogleraar Elizabeth de Lange is op 31 januari geëerd door de Universiteit van Uppsala, die haar eind 2019 benoemde tot eredoctor. Tijdens de ceremonie ontving De Lange de drie symbolen van eer voor een eredoctoraat: een hoed, een diploma en een ring. ‘Een ongelofelijk prachtige ervaring!’
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PhD candidate, Computational modelling for drug safety prediction
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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PhD Position in the Virtual Human for Safety (VHP4Safety) Project
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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This Week's Discoveries | 7 May 2019
Lezing
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Chemical approaches to control the in vivo behavior of nanomedicines
Lezing, Van Leeuwenhoek Lecture on BioScience