39 zoekresultaten voor “pharmacokinetics” in de Publieke website
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
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clinical studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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The impact of obesity on the pharmacokinetics of drugs in adolescents and adults
Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Pharmacology based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof
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The quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Population Pharmacokinetic and Pharmacodynamic Analysis in Anesthesia
Promotie
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
Promotie
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Tamoxifen pharmacogenetics and pharmacokinetics in early-breast cancer
Promotie
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Afscheidssymposium Prof. dr. M. Danhof: "Four decades of Research in Pharmacokinetics, Pharmacodynamics and beyond...",
Congres/symposium
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Comorbidities, complications and treatment of childhood obesity
Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.
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Pharmacogenomics in Drug Development: Implementation and Application of PKPD Model Based Approaches
Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …
- clinical studies in special populations: towards semi-physiological pharmacokinetic models
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Promotie
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Weinig bewijs dat doping écht werkt
De lijst met verboden middelen van het Wereld Anti-Doping Agentschap (WADA) is enorm. Promovendus Jules Heuberger nam een groot deel ervan onder de loep, net als de detectiemethoden. Hij concludeerde: er is voor maar weinig stoffen bewijs dat ze daadwerkelijk de prestatie bevorderen. Promotie op 16…
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
Promotie
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The impact of obesity on the pharmacokinetics of drugs in adolescents and adults
Promotie
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Promotie
- Onderzoeksoutput
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Aan de wieg van farmacologische modellen
Na 41 jaar neemt Meindert Danhof, hoogleraar Farmacologie, op 31 maart afscheid van het Leiden Academic Centre for Drug Research. Een symposium ter ere van hem, voorafgaand aan het afscheidscollege, laat zien wat er in die periode bereikt is. Danhof kijkt met plezier terug.
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Research Achievement Award voor Meindert Danhof
Prof.dr. Meindert Danhof ontving op 15 november een Research Achievement Award in Pharmacokinetics, Pharmacodynamics & Drug Metabolism.
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Hersenonderzoek doen alsof je Mastermind speelt
De hersenen zijn een complex weefsel, en onderzoek doen naar medicijnen voor hersenaandoeningen is zo mogelijk nog complexer. Elizabeth (Liesbeth) de Lange, hoogleraar Voorspellende Farmacologie, pleit voor een zeer gestructureerde aanpak. ‘Het is eigenlijk net als Mastermind spelen.’ Oratie op 22 m…
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PHD candidate, Mathematical modeling for prediction of liver toxicity
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Elke Krekels ontvangt Publicatieprijs Nederlandse Vereniging van Klinische Farmacologie
Krekels heeft zowel de Thesis Award als de TOP-Publicatieprijs ontvangen voor haar proefschrift ‘Size does matter: drug glucuronidation in children.’ Haar onderzoek leidde tot een nieuw doseervoorschrift van morfine voor baby’s en peuters. Beide prijzen werden uitgereikt tijdens de wetenschappelijke…
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Mastermind spelen om Alzheimer te ontrafelen
Om het ziekteverloop van de Ziekte van Alzheimer beter te begrijpen, is volgens Frédérique Kok een strategische en gestructureerde aanpak nodig: de Mastermindmethode. Met haar LUF-subsidie wil Kok data van hoge kwaliteit verzamelen om een wiskundig model maken dat het ontstaan van de ziekte kan herkennen…
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Eredoctor Elizabeth de Lange geëerd in Uppsala
Hoogleraar Elizabeth de Lange is op 31 januari geëerd door de Universiteit van Uppsala, die haar eind 2019 benoemde tot eredoctor. Tijdens de ceremonie ontving De Lange de drie symbolen van eer voor een eredoctoraat: een hoed, een diploma en een ring. ‘Een ongelofelijk prachtige ervaring!’
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This Week's Discoveries | 7 May 2019
Lezing
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Chemical approaches to control the in vivo behavior of nanomedicines
Lezing, Van Leeuwenhoek Lecture on BioScience