34 zoekresultaten voor “pediatric renal clearance” in de Publieke website
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glomerular filtration and active tubular secretion in predicting renal clearance in children using population pharmacokinetic and physiology based
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
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Complement activation in renal microangiopathies
Promotie
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glomerular filtration and active tubular secretion in predicting renal clearance in children using population pharmacokinetic and physiology based
Promotie
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Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
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ANCA-associated vasculitis: On clinical management and renal outcome
Promotie
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Enhanced monitoring and screening in pediatric coeliac disease
Promotie
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Treosulfan pharmacokinetics and dynamics in pediatric allogeneic stem cell transplantation
Promotie
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
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Optimization of suntinib treatment in metastatic renal cell carcinoma: pharmacogenetic evidence and challenges
Promotie
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Targeting autoimmunity in renal diseases: focus on neutrophil extracellular traps and autoreactive B-cells
Promotie
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Shear stress regulated signaling in renal epithelial cells and polycystic kidney disease
Promotie
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Molecular pathways involved in renal injury-repair and ADPKD progression
Promotie
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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Medicijngebruik door adoptiekinderen
Internationaal geadopteerde kinderen gebruiken niet meer medicijnen dan hun niet-geadopteerde leeftijdgenoten.
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
Promotie
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Targeted Informed consent: empowering young participants in medical-scientific research
Promotor: J.M. van den Broek Co-promotor: M.C. de Vries
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
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2 PhD candidates to study the molecular mechanisms of the Hsp70 chaperone in neurodegenerative disease
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Over het TRIXY Team
Het team van wetenschappers binnen TRIXY Expertisecentrum zorgt ervoor dat belangrijke kennis verzameld wordt over kwetsbaarheden bij deze kinderen.
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Bezoek de Leidse voorronde van FameLab
Welke twee Leidse bètawetenschappers presenteren hun onderzoek het aanstekelijkst in drie minuten? Misschien wel degenen met de meeste supporters. Op 14 februari vindt de Leidse voorronde van FameLab plaats. Meld je nu aan als publiek!
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Transgenderjongeren kunnen goed zelf beslissen over puberteitsremmers
Transgenderjongeren blijken wilsbekwaam om samen met hun ouders te beslissen over een omkeerbare interventie met puberteitsremmers. Dat blijkt uit een studie van LUMC Curium en Amsterdam UMC onder 74 jongeren in behandeling. Van de onderzochte jongeren bleek 90% in staat te zijn om een afgewogen beslissing…
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Consortia krijgen subsidie voor onderzoek naar urgente vraagstukken
Meerdere consortia waarin de Universiteit Leiden is vertegenwoordigd gaan aan de slag met interdisciplinair onderzoek waarmee wetenschappelijke en maatschappelijke doorbraken binnen bereik komen. In de projecten werken kennisinstellingen, overheden en private partijen nauw samen.
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