897 zoekresultaten voor “parkinson s disease” in de Publieke website
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.
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Pesticides and health – challenges and opportunities for exposure assessment
The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…
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Specifiek eiwit in de hoofdrol bij ziekte van Parkinson
Met elektronspins hebben natuurkundigen het bindingsproces onderzocht van het eiwit α-synucleïne, dat wordt geassocieerd met de ziekte van Parkinson. Wat blijkt is dat het eiwit op een verrassend efficiënte manier bindt aan een hersenmembraan. Met deze in Leiden ontwikkelde methode hebben de onderzoekers…
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Nieuwe stoffen remmen ontsteking in het brein
Leidse chemisch biologen, onder leiding van dr. Mario van der Stelt, hebben stoffen ontdekt die ontstekingsprocessen in de hersenen kunnen verminderen. Daarmee is een eerste stap gezet in de ontwikkeling van potentiële geneesmiddelen voor de behandeling van hersenziekten zoals de ziekten van Alzheimer…
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New neuroimaging approaches in Parkinson's disease
Promotie
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Clinical predictors of disease progression in Parkinson's disease
Promotie
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Parkinson’s protein α-synuclein: membrane interactions and fibril structure
The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.
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Activity-based protein profiling of diacylglycerol lipases
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Monitoring Alzheimer's disease in transgenic mice with ultra high field magnetic resonance imaging
Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia
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This Week's Discoveries | 11 June 2019
Lezing
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Hoefijzereiwit schakel in Parkinson
De Leidse biofysica Martina Huber was de eerste die ontdekte dat een eiwit dat mede verantwoordelijk is voor de ziekte van Parkinson de vorm van een verstrengeld hoefijzer kan hebben. Een bijzondere ontdekking want het eiwit is nagenoeg onzichtbaar.
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This Week’s Discoveries | 13 February 2018
Lezing
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glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Circulating cells as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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Menière's disease: clinical aspects, diagnostic tests and interventions
Promotie
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S SudarmokoFaculteit der Geesteswetenschappen
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S van der VlietFaculteit der Geesteswetenschappen
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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Zebrafish as vertebrate model of Gaucher disease
Promotie
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Phenotyping cardiometabolic disease with magnetic resonance techniques
Promotie
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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Parkinson’s Protein α-Synuclein: Membrane Interactions and Fibril Structure
Promotie
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Macrophage activation and cholesterol in atherosclerosis development
Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…
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Risk factors of Chronic Kidney Disease Progression: Dutch Cohort studies
Promotie
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Novel insights into blood markers and cardiovascular disease
Promotie
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candidate “Personalized rewards of lifestyle changes in cardiovascular diseases”
Sociale Wetenschappen, Psychologie
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Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
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Nieuw project om ziekte van Alzheimer te bestuderen
Onderzoekers van de Universiteit Leiden gaan een nieuwe manier ontwikkelen om de biomarkers van de ziekte van Alzheimer te bestuderen. De aanpak focust zich op de moleculaire boodschappers van de cellen. Het project, geleid door Thomas Hankemeier en gecoördineerd door Yuliya Shakalisava (Leiden Academic…
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Suicidality in Huntington's disease
Promotie
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phenotypes in human pluripotent stem cell derived cardiomyocytes for disease modelling and drug discovery
Promotie
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biology of common and grey seals along the Dutch coast : stranding, disease, rehabilitation and conservation
Promotores: H.A. Udo De Haes, P.M. Brakefield
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper
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Natural and non-natural factors influencing Alzheimer´s Aβ
Promotor: Prof.dr. J.P. Abrahams
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot
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Transfer of "goods" from plants to humans: Fundamental and applied biochemical investigations on retaining glycosidases
The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.
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Hoefijzervormige ‘Parkinsoneiwitten’ vormen klonten
Er is weer nieuws over het eiwit alpha-Synucleine. dat een belangrijke rol wordt toegedicht bij de ziekte van Parkinson. Biofysicus Martina Huber e.a. laten zien op welke manier deze eiwiten samenklonteren als ze met een membraan in contact komen. Hun artikel in de Journal of the American Chemical Society…
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Huntington's disease Cognition and Apathy
Promotie
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Veni-beurs voor Lucia Bossoni
Postdoc Lucia Bossoni heeft een NWO Veni in de wacht gesleept. Ze gebruikt de beurs om de komende drie jaar onderzoek te doen naar hersenziekten in labs op zowel het LUMC als het Leidse natuurkunde-instituut.
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Knowledge discovery methods for Huntington’s Disease
Promotie
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Music therapy in Huntington's disease
Promotie
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Blood and biomarkers in Huntington’s Disease
Promotie
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Neuropsychiatric phenomena in Huntington's disease
Promotie
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Dyslipidemia, metabolism and autophagy: antigen-independent modulation of T cells in atherosclerosis
Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.
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Macrophage activation and cholesterol in atherosclerosis development
Promotores:Th.J.C. van Berkel, M. van Eck
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The UHDRS and UHDRS-FAP assessments in Huntington’s disease
Promotie