It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

To deliver a Virtual Sensor tool optimised to exploit the synergy between Sentinels 2 and 3 to allow the consistent retrieval of land surface parameters (Albedo, LAI, and LST); To extend the existing capabilities of land EO data assimilation tools to add capacity to handle data in the thermal domain…

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.

Description of Atlas of the surfacewater concentrations of pesticides in the Netherlands, a pilotstudy.

Promotor: Prof.dr. R.M.H. Merks

Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Bachelor, Master, PhD

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

D1.3 describes a set of five case studies relevant in the context of the EuDEco project. Case studies are considered relevant if they are initiatives focusing on the promotion of big data and data reuse or pilots facilitating data reuse in one form or the other. The case studies were expected to allow…

Promotor: W. Jiskoot, Co-promotor: H.A. Every

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Het Centre for the Study of Political Parties and Representation (CSPPR) is een interdisciplinair platform voor onderzoekers van de Universiteit Leiden. De focus ligt op het functioneren van politieke partijen in heden en verleden. In het bijzonder wordt gekeken naar de oorzaken en gevolgen van veranderende…

An overview is given of the flows of chlorine and chlorinated hydrocarbons through the Europian Union.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Promotor: Prof.dr. G.P. van Wezel

Minister Koolmees van Sociale Zaken en Werkgelegenheid heeft Marike Knoef benoemd in de Commissie Parameters, onder voorzitterschap van oud-minister van Financiën Jeroen Dijsselbloem.

Promotores: F.H.J. Redig, W.T.F. den Hollander

Promotor: B.van de Water, Co-promotor: L.S.Price

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

This thesis describes a study from both a theoreticaL and an experimental point of view.

Centraal in dit proefschrift staan de perspectieven van docenten met betrekking tot zelfstandig leren.

Op 19 september 2019 verdedigde Lynette Janssen zijn proefschrift 'EU Bank Resolution Framework: A comparative study on the relation with national private law'. Het promotieonderzoek is begeleid door promotoren prof.mr. W.A.K. Rank en prof.mr. M. Haentjens.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

A century ago, it was unclear whether the stars in the sky were clustered in groups, or widely spread in the universe.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

This project aims to develop advanced data analysis methods for monitoring and increasing our understanding on biodiversity dynamics in nature reserves such as the Oostvaardersplassen.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

Quantifying physical activity (using accelerometers) and combining the frequency and intensity of activities with health data (brain MRI, traditional clinical parameters and metabolomics) is of utmost importance to monitor mobility and health among older individuals and study health promotion during…

Een vergelijkende analyse van legitimeringsstrategieën in drie landen: Rusland, Venezuela en de Seychellen.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Promotor: Prof.dr. H.V.J. Linnartz

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

Including modelling as part of software development appears to have various benefits.

Promotor: Prof.dr. K.J. Batenburg

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Op 1 december 2020 verdedigde Bernadette Muscat haar proefschrift 'Insolvency Close-out Netting: A comparative study of English, French and US laws in a global perspective'. Het promotieonderzoek is begeleid door promotoren prof.mr.drs. M. Haentjens en prof.mr. B. Wessels.

Aan de hand van een reeks case studies in Irak, Moldavië en Servië gedurende het post-Koude Oorlogstijdperk, onderzoekt dit boek asymmetrische conflicten waarbij de strijdende partijen een grote ongelijkheid in machtsposities vertonen.

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Which factors (human-dimension and carnivore related) shape human tolerance of large carnivore and large carnivore survival in multiple use forests?