Promotor: Prof.dr. R.M.H. Merks

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

To deliver a Virtual Sensor tool optimised to exploit the synergy between Sentinels 2 and 3 to allow the consistent retrieval of land surface parameters (Albedo, LAI, and LST); To extend the existing capabilities of land EO data assimilation tools to add capacity to handle data in the thermal domain…

A century ago, it was unclear whether the stars in the sky were clustered in groups, or widely spread in the universe.

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Description of Atlas of the surfacewater concentrations of pesticides in the Netherlands, a pilotstudy.

Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Bachelor, Master, PhD

Promotor: Prof.dr. K.J. Batenburg

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Minister Koolmees van Sociale Zaken en Werkgelegenheid heeft Marike Knoef benoemd in de Commissie Parameters, onder voorzitterschap van oud-minister van Financiën Jeroen Dijsselbloem.

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

D1.3 describes a set of five case studies relevant in the context of the EuDEco project. Case studies are considered relevant if they are initiatives focusing on the promotion of big data and data reuse or pilots facilitating data reuse in one form or the other. The case studies were expected to allow…

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Het Centre for the Study of Political Parties and Representation (CSPPR) is een interdisciplinair platform voor onderzoekers van de Universiteit Leiden. De focus ligt op het functioneren van politieke partijen in heden en verleden. In het bijzonder wordt gekeken naar de oorzaken en gevolgen van veranderende…

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Promotor: Prof.dr. G.P. van Wezel

Promotor: B.van de Water, Co-promotor: L.S.Price

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Een vergelijkende analyse van legitimeringsstrategieën in drie landen: Rusland, Venezuela en de Seychellen.

Centraal in dit proefschrift staan de perspectieven van docenten met betrekking tot zelfstandig leren.

Promotor: J. Aarts

Promotor: Prof.dr. A.W. van der Vaart

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

Promotores: F.H.J. Redig, W.T.F. den Hollander

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Including modelling as part of software development appears to have various benefits.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Promotor: H.V.J. Linnartz

Op 19 september 2019 verdedigde Lynette Janssen zijn proefschrift 'EU Bank Resolution Framework: A comparative study on the relation with national private law'. Het promotieonderzoek is begeleid door promotoren prof.mr. W.A.K. Rank en prof.mr. M. Haentjens.

This thesis describes a study from both a theoreticaL and an experimental point of view.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

Promotor: Prof.dr. H.V.J. Linnartz