193 zoekresultaten voor “paramagnetic nmr probes” in de Publieke website
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Design, synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
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Applications of paramagnetic NMR spectroscopy for protein research
The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.
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Classical and paramagnetic NMR spectroscopy applied to different protein systems
Promotor: Prof.dr. M. Ubbink
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Deciphering the complex paramagnetic NMR spectra of small laccase
Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.
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Making the invisible visible: paramagnetic NMR and the transient protein complex
Promotor: Prof.dr. M. Ubbink
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of the cytochrome P450cam-putidaredoxin complex determined by paramagnetic NMR spectroscopy and crystallography
Promotor: Prof.dr. M. Ubbink
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NMR Faciliteit
Met de NMR faciliteit doen we onderzoek naar de synthese van paramagnetische moleculen om kennis te vergaren over de structuur en dynamiek van eiwitten. Deze kennis kan dienen als basis voor een medicijn dat zich hecht aan een eiwit of voor de ontwikkeling van vaccins. Medicijnontwikkeling is één van…
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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NMR structural studies of protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal
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Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B
Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.
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Understanding functional dynamics and conformational stability of beta-glycosidases
Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.
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Marcellus UbbinkWiskunde en Natuurwetenschappen
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Inhibitors and probes targeting endo-glycosidases
The chemical synthesis of inhibitors and probes targeting endo-glycosidases.
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Nuclear magnetic resonance force microscopy at millikelvin temperatures
Promotor: T.H. Oosterkamp
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structural study of light-harvesting complexes : an investigation with MAS-NMR
Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.
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Peptide-based probes for protein N-Methyltransferases
The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Chemical Protein Synthesis: from Nanobodies to Activity-Based Probes
Promotie
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18.5 miljoen voor grootschalige NMR onderzoeksfaciliteit
Het programma ‘uNMR-NL’, een project om een 1.2 GHz NMR spectrometer in Nederland te plaatsen voor chemisch onderzoek, heeft 18,5 miljoen euro ontvangen om deze grootschalige faciliteit op te zetten. Dit wordt vanmiddag in Utrecht bekend gemaakt door staatssecretaris Zijlstra van OCW en Jos Engelen,…
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Understanding protein complex formation: The role of charge distribution in the encounter complex
Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.
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Officiële opening paramagnetische NMR-faciliteit
De nieuwe Leidse paramagnetische Nuclear Magnetic Resonance (paraNMR)-faciliteit wordt op woensdag 11 september officieel geopend. De faciliteit biedt externe gebruikers, zowel nationaal als internationaal, expertise op het zeer geavanceerde terrein van paraNMR-onderzoek.
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Towards photo-CIDNP MAS NMR as a generally applicable enhancement method
Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)
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Applications for activity-based probes in biomedical research on glycosidases
Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Synthetic peptides, nucleic acids and molecular probes to study ADP-Ribosylation
This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.
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structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based metabolomics approach
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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Forse investering in Leids centrum voor NMR spectroscopie
Paramagnetisme. Een nieuwe occulte praktijk? Nee. Een van de nieuwste wetenschappelijke methoden om het gedrag van eiwitten haarscherp in kaart te brengen. Marcellus Ubbink van de Universiteit Leiden krijgt ruim 3 miljoen euro van de Nederlandse Organisatie voor Wetenschappelijk Onderzoek en de Universiteit…
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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Verhuizing 750 MHz NMR spectrometer
Op 2 april is de 750 MHz NMR spetrometer verhuisd van het LMUY gebouw naar de nieuwbouw van de Science Campus.
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Gewichtige operatie; 850 MHz NMR spectrometer geleverd aan Leids NMR centrum
De hele dag is met man en macht gewerkt om de 4000 kilo zware magneet van de spectrometer van de vrachtwagen af te takelen en door de gangen van de Leidse bètafaculteit te loodsen. Niet helemaal zonder gevaren want de vloeren in het gebouw zijn niet berekend op zoveel gewicht. Dankzij de nodige voorzorgsmaatregelen…
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ECHO-subsidie voor Marcellus Ubbink
Marcellus Ubbink, hoogleraar Eiwitchemie, heeft een ECHO-subsidie van NWO ter waarde van 260 duizend euro in de wacht gesleept. Met het geld gaat hij onderzoek doen naar enzymremmers.
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Parkinson’s protein α-synuclein: membrane interactions and fibril structure
The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.
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17.9 miljoen euro subsidie voor NMR Roadmap consortium
De Nationale roadmap grootschalige wetenschappelijke infrastructuur van NWO maakt de bouw of vernieuwing mogelijk van onderzoeksfaciliteiten met een internationale uitstraling. Leidse NMR onderzoeksgroepen maken deel uit van het uNMR-NL consortium dat recent bijna 18 miljoen euro subsidie heeft ontvangen.…
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Deciphering the complex paramagnetic NMR spectra of small laccase
Promotie
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applications of paramagnetic NMR spectroscopy for protein research
Promotie
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Spin-label EPR Approaches to Protein Interactions
Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber
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Factors affecting galanthamine production in Narcissus
Factors affecting galanthamine production in Narcissus
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Cyclophellitol analogues for profiling of exo- and endo-glycosidases
To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.
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Chemical tools to modulate endocannabinoid biosynthesis
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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The relation between dynamics and activity of phospholipase A/acyltransferase homologs
Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.
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Cyclophellitol and its derivatives: synthesis and application as beta-glycosidase inhibitors
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Magnetic resonance force microscopy for condensed matter
In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.
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Metabolomic characteristics of Catharanthus roseus plants in time and space
Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa
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Non-target effects of GM potato: an eco-metabolomics approach
Promotores: P.G.L. Klinkhamer, P.M. Brakefield, Co-Promotor: M. Bruinsma
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Connecting dots between natural and artificial Photosynthesis
Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.
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Design, synthesis and application of paramagnetic probes for protein structure studies
Promotie
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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The heart of oxygenic photosynthesis illuminated
Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia
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Werking versterkstoffen MRI in kaart gebracht
Speciale versterkstoffen kunnen MRI-scanners honderden malen gevoeliger maken. Leidse fysici hebben nu een methode gevonden om hun efficiëntie te toetsen. Gevoeligere MRI-scans kunnen bijvoorbeeld taaislijmziekte of Parkinson begrijpelijker maken. Publicatie op 18 januari in PCCP.