An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Lezing

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotor: G.R. de Snoo

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Op voordracht van prof.dr. Roderich Suessmuth van de Technische Universiteit van Berlijn ontving prof.dr. Herman Overkleeft de Friedrich Wilhelm Bessel Research Award. Van Overkleeft is in Leiden verbonden aan het Leiden Institute of Chemistry, LIC/Bio-organic Synthesis.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Freek Janssen kreeg tijdens de FIGON Dutch Medicine Days 2015 op 5 oktober in Ede de KNCV Farmacochemie prijs voor beste presentatie uitgereikt. Janssen ontvangt deze prijs voor zijn presentatie "Discovery and optimization of highly selective and reversible diacylglycerol lipase inhibitors".

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Hoe kunnen we met behulp van moleculair gereedschap meer inzicht krijgen in de ziekteverwekkende eigenschappen van de Neisseria pili?

Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…

Promotor: H.V.J. Linnartz

Met de NMR faciliteit doen we onderzoek naar de synthese van paramagnetische moleculen om kennis te vergaren over de structuur en dynamiek van eiwitten. Deze kennis kan dienen als basis voor een medicijn dat zich hecht aan een eiwit of voor de ontwikkeling van vaccins. Medicijnontwikkeling is één van…

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR), Leids Instituut voor Chemisch Onderzoek (LIC)

Wetenschappers van de Universiteit Leiden hebben een doorbraak bereikt in de bestudering van de erfelijke stofwisselingsziekte van Pompe. Samen met hun Yorkse collega’s ontwierpen zij een molecuul dat zich bindt aan het enzym dat aan de basis staat van het ziekteverloop. De bevindingen zijn gepubliceerd…

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Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Promotor: Prof.dr.ir. E. Deprettere

Promotor: Prof.dr. G.P. van Wezel

Lezing

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Twee jonge excellente chemici, Jeroen Codée en Sander van Kasteren, hebben een ECHO subsidie van € 260.000 euro toegekend gekregen door de Nederlandse Organisatie voor Wetenschappelijk Onderzoek. Hiermee kunnen hun onderzoeksprojecten van start gaan.

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