Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotor: G.R. de Snoo

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

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The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Hoe kunnen we met behulp van moleculair gereedschap meer inzicht krijgen in de ziekteverwekkende eigenschappen van de Neisseria pili?

Op voordracht van prof.dr. Roderich Suessmuth van de Technische Universiteit van Berlijn ontving prof.dr. Herman Overkleeft de Friedrich Wilhelm Bessel Research Award. Van Overkleeft is in Leiden verbonden aan het Leiden Institute of Chemistry, LIC/Bio-organic Synthesis.

Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…

Freek Janssen kreeg tijdens de FIGON Dutch Medicine Days 2015 op 5 oktober in Ede de KNCV Farmacochemie prijs voor beste presentatie uitgereikt. Janssen ontvangt deze prijs voor zijn presentatie

Promotor: H.V.J. Linnartz

Thomas Bakkum en Tom van der Wel, promovendi bij het Leids Instituut voor Chemisch Onderzoek, winnen poster awards bij de EMBL Chemical Biology Conference 2018 in Heidelberg.

Promotor: Prof.dr. G.P. van Wezel

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

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Thomas Hansen ontvangt op 28 november de AkzoNobel Graduation Prize for Chemistry and Process Engineering bij de Koninklijke Hollandsche Maatschappij der Wetenschappen (KHMW) te Haarlem. Hij wint deze prijs voor fundamenteel onderzoek naar de glycosyleringsreactie, de meest gebruikte reactie in de synthese…

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

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Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

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Lezing

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The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Promotores: W. Jiskoot, F. Ossendorp

Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…

Electron microscopy has become an extremely important techniquein a wide variety of elds.

Consequences for sediment stability and seston trapping

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The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L. Kaper (UvA)

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.