181 zoekresultaten voor “organic synthesis” in de Publieke website
-
'Q-wires': Synthesis, electrochemical properties and their application in electro-enzymology
An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.
-
Synthesis of phosphodiester-containing bacterial cell wall components: teichoic acids, capsular polysaccharides and phosphatidyl glycerol analogues
Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée
-
1,2-cis-glycosylations: method development and synthesis of complex oligosaccharides
Promotor: G.A. van der Marel, Co-promotor: D.C. Codée
-
Synthesis and application of glycans unique to S. Mansoni
Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.
-
Breeding birds on organic and conventional arable farms
Promotor: G.R. de Snoo
-
Self adjuvanting immunopeptides: Design and synthesis
Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.
-
PhD candidate, for the chemical synthesis of immune modulating molecules
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
-
Total Synthesis of Alginate and Zwitterionic Sp1 Oligosaccharides
The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.
-
Novel Protecting Group Strategies in the Synthesis of Oligosaccharides
The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.
-
Reagent Controlled Synthesis of 1,2-cis-Oligosaccharides
This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…
-
Iminosugars as glucosylceramide processing enzymes inhibitors: design, synthesis and evaluation
This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.
-
The synthesis of mannose-derived bioconjugates and enzyme inhibitors
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee
-
Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
-
The synthesis of chemical tools for studying sphingolipid metabolism
Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.
-
Synthesis of well-defined ADP-Ribosylated biomolecules
Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov
-
Exploring Images With Deep Learning for Classification, Retrieval and Synthesis
In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.
-
Synthesis of oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
-
Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
-
Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
-
Design, synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
-
NMR Faciliteit
Met de NMR faciliteit doen we onderzoek naar de synthese van paramagnetische moleculen om kennis te vergaren over de structuur en dynamiek van eiwitten. Deze kennis kan dienen als basis voor een medicijn dat zich hecht aan een eiwit of voor de ontwikkeling van vaccins. Medicijnontwikkeling is één van…
-
The formation of complex organic molecules in dense clouds-Sweet results from laboratory
Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.
-
Reactivity and Selectivity in Glycosylation Reactions
The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.
-
A chemical biology approach for targeting of ligand-drug conjugates
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot
-
Synthesis of glycopeptides and phosphoglyceropeptides to characterize and detect posttranslational modifications of Neisseria pili
Hoe kunnen we met behulp van moleculair gereedschap meer inzicht krijgen in de ziekteverwekkende eigenschappen van de Neisseria pili?
-
Cyclophellitol and its derivatives: synthesis and application as beta-glycosidase inhibitors
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
-
Postdoctoral researcher in the field of supramolecular chemistry
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
-
Understanding functional dynamics and conformational stability of beta-glycosidases
Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.
-
PhD candidate in the field of supramolecular chemistry
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
-
Exposure and health Assessment of Persistent Organic Pollutants (POPs) at e-waste recycling site among workers in the informal sector in Nigeria
Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…
-
Dark ice chemistry in interstellar clouds
This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.
-
Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
-
Hermen Overkleeft ontvangt Friedrich Wilhelm Bessel Research Award
Op voordracht van prof.dr. Roderich Suessmuth van de Technische Universiteit van Berlijn ontving prof.dr. Herman Overkleeft de Friedrich Wilhelm Bessel Research Award. Van Overkleeft is in Leiden verbonden aan het Leiden Institute of Chemistry, LIC/Bio-organic Synthesis.
-
Dirk-Jan Kok
Wiskunde en Natuurwetenschappen
-
Hermen Overkleeft wint de 2015 Jeremy Knowles Award
Prof. Hermen Overkleeft is bekroond met de 2015 Jeremy Knowles Award van de Royal Society of Chemistry voor zijn innovatieve en inzichtelijke ontwikkeling van activity-based eiwit probes voor de beeldvorming en de identificatie van enzymen in gezondheid en ziekte. Van Overkleeft is in Leiden verbonden…
-
Freek Janssen wint KNCV Farmacochemie prijs voor beste presentatie
Freek Janssen kreeg tijdens de FIGON Dutch Medicine Days 2015 op 5 oktober in Ede de KNCV Farmacochemie prijs voor beste presentatie uitgereikt. Janssen ontvangt deze prijs voor zijn presentatie
-
Luminescence and applications of lanthanoid coordination polymers
Promotor: E. Bouwman, Co-Promotor: S. Bonnet
-
Shining Light on Interstellar Matter
Promotor: H.V.J. Linnartz
-
Willie Peijnenburg
Wiskunde en Natuurwetenschappen
-
Estimation and Optimization of the Performance of Polyhedral Process Networks
Promotor: Prof.dr.ir. E. Deprettere
-
Dennis Hetterscheid
Wiskunde en Natuurwetenschappen
-
Jeroen Codee
Wiskunde en Natuurwetenschappen
-
Dubbel succes bij de EMBL Chemical Biology Conference
Thomas Bakkum en Tom van der Wel, promovendi bij het Leids Instituut voor Chemisch Onderzoek, winnen poster awards bij de EMBL Chemical Biology Conference 2018 in Heidelberg.
-
Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
-
Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
-
Development of synthetic procedures towards immunostimulating carbohydrates
Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée
-
Full Professor in Artificial Intelligence in Medicinal Chemistry
Wiskunde en Natuurwetenschappen
-
Synthetic Study on ADP-ribosylation
This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.
-
Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
-
Doorbraak Leidse wetenschappers in bestuderen ziekte van Pompe
Wetenschappers van de Universiteit Leiden hebben een doorbraak bereikt in de bestudering van de erfelijke stofwisselingsziekte van Pompe. Samen met hun Yorkse collega’s ontwierpen zij een molecuul dat zich bindt aan het enzym dat aan de basis staat van het ziekteverloop. De bevindingen zijn gepubliceerd…