Promotor: G.R. de Snoo

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Elk onderdeel van de kringloop op een melkveebedrijf heeft een specifieke bacterie- en schimmelsamenstelling. Dat ontdekten de Leidse postdoc onderzoeker Sofia Gomes en haar begeleiders Nadia Soudzilovskaia en Peter van Bodegom in samenwerking met het Louis Bolk instituut en Naturalis Biodiversity Centre.…

Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Promotor: H.V.J. Linnartz

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Promotor: Prof.dr. G.P. van Wezel

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotor: Prof.dr. G.R. de Snoo

Does knowledge of environmental performance change farmer's behaviour?

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Promotie

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Met de NMR faciliteit doen we onderzoek naar de synthese van paramagnetische moleculen om kennis te vergaren over de structuur en dynamiek van eiwitten. Deze kennis kan dienen als basis voor een medicijn dat zich hecht aan een eiwit of voor de ontwikkeling van vaccins. Medicijnontwikkeling is één van…

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Promotor: M.A.G.J. Orrit

Promotie

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Promotie

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Promotie

Promotores: E. van Dijk, G.R. de Snoo. Co-promotor: H. Staats

Promotor: G.R. de Snoo, Co-promotor: C.J.M. Muster

Promotie

What are the environmental trade-offs for SMEs considering moving from monoculture aquaculture practice towards IMTA? What are the environmental trade-offs comparing IMTA species with their conventional monoculture alternatives?

Electron microscopy has become an extremely important techniquein a wide variety of elds.

Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Consequences for sediment stability and seston trapping

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotores: W. Jiskoot, F. Ossendorp