Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.

Promotor: Prof.dr. M.A.G.J. Orrit

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

This thesis consists of two subjects, that are both a consequence of radiation pressure.

Bram Koster, hoogleraar Elektron Microscopy, is benoemd tot directeur van NeCEN, de geavanceerde cryo- elektronenmicroscopie faciliteit van de faculteit. Koster wil meer samenwerking op het gebied van onderzoek, nieuwe imaging technieken ontwikkelen en een nieuwe postdoctorale training opzetten voor…

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

We investigate how radiation pressure can be used to influence the mechanical motion of a micro-mirror suspended from springs.

Promotor: M.A.G.J. Orrit

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

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In the thesis we demonstrated an 85% state transfer efficiency between two mechanical modes coupled to a common optical mode via stimulated Raman adiabatic passage (STIRAP) in the classical regime. We also showed possibilities to manipulate quantum states of the mechanical modes via STIRAP.

In this thesis, we use low-frequency and high-frequency radio observations to address the following questions regarding quasars: is the radio loud/quiet quasar dichotomy real?

Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

A century ago, it was unclear whether the stars in the sky were clustered in groups, or widely spread in the universe.

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

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Met een slag op de knop maakte gedeputeerde Liesbeth Spies een live verbinding met een microscoop 70 meter verderop. Hiermee opende ze op 27 oktober officieel het Netherlands Centre for Electron Nanoscopy NeCEN. NeCEN heeft de twee meest geavanceerde cryo-transmissie elektronenmicroscopen voor biologische…

Het Netherlands Centre for Electron Nanoscopy (NeCEN) in Leiden opent zijn deuren op 27 oktober 2011. NeCEN geeft iedereen toegang tot de meest geavanceerde cryo-transmissie-elektronenmicroscopen ter wereld. Tien academische partners, lokale en nationale overheden en bedrijven werkten samen om dit centrum…

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Tijdens de Leiden Science Family Day kom je op plekken die normaal voor het publiek gesloten blijven: ga backstage bij de faculteit der Wiskunde en Natuurwetenschappen!

The origin and evolution of galaxies are closely linked to many different physical phenomena.

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

Op 3 juni 2015 bezocht een delegatie van het onderzoekscentrum voor biotechnologie in Praag (BIOCEV) de Faculteit der Wiskunde en Natuurwetenschappen in Leiden. De delegatie bezocht onder andere Netherlands Centre for Electron Microscopy (NeCEN), om mogelijkheden voor samenwerking op het gebied van…

Alireza Mashaghi van het Leiden Academic Centre for Drug Research (LACDR) zal met behulp van de modernste technologie verkeerd gevouwen eiwitten onderzoeken die een rol spelen bij spierdystrofie. Zijn doel: tot nieuwe inzichten komen die in de toekomst leiden tot nieuwe therapieën. Mashaghi ontvangt…

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De Nederlandse organisatie voor Wetenschappelijk Onderwijs (NWO) kent ruim 17 miljoen subsidie toe aan het verder ontwikkelen van een Nederlands netwerk voor elektronenmicroscopie (NEMI). Het netwerk bestaat uit vijf UMC’s en acht universiteiten, met Utrecht als coördinator. Vanuit de Universiteit Leiden…

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

Promotor: T. Schmidt

This thesis describes the Multi-site All-Sky CAmeRA (MASCARA), which consists of two small robotic telescope designed to detect exoplanets around the brightest stars in the sky.

Promotores: A.H. Meijer, H.P. Spaink

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Surface plasmons (SPs) are surface waves at the interface between a dielectric and a good metal, and are formed by the interaction between light and the free electrons at the metal-dielectric interface. They provide strong field confinement for optical fields, opening new possibilities for enhanced…

Promotor: A. Kros

To study how planetary systems come into existence we study much younger systems still in formation.

In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.