Promotor: Prof.dr. S.F. Portegies Zwart

Promotores: S.F. Portegies Zwart, E. M. Rossi

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

A century ago, it was unclear whether the stars in the sky were clustered in groups, or widely spread in the universe.

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

Unfolding potential

Promotor: K.H. Kuijken

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

Promotor: Prof.dr. E. F. van Dishoeck

One of the most important puzzles in modern astrophysics is the nature of dark matter.

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

Veel kinderen leren niet op een niveau dat aansluit bij hun potentieel om te leren. Diagnostiek in de leerlingbeleiding zou daarom inzicht moeten geven in hoe een kind begeleid kan worden in het verder ontwikkelen van zijn of haar sterke kanten terwijl het tegelijkertijd handvatten biedt voor het ondersteunen…

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

Promotor: W.Th.F. den Hollander

Promotor: J.W. van Holten

An assessment approach that tailors to children’s instructional needs

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Hoe beinvloed de structuur van één enkel gen de activiteit van genen die gevoelig zijn voor hormonen?

Het artikel 'Flexible updating of dynamic knowledge structures' met bijdrage van Franziska Richter van Cognitieve Psychologie is uitgebracht door Nature.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

Developing methodes to understand the evolution of patches in natural ecosystems

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Promotor: Prof.dr. G.J. Kroes

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

Het onderzoek in dit proefschrift kijkt naar de rol van het locus ceuruleus - noradrenalinesysteem in verscheidene aspecten van menselijke cognitie, en de modulatie van de staat van het brein.

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L. Kaper (UvA)

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Het verzamelen en interpreteren van grote hoeveelheden data is niet meer weg te denken uit de maatschappij en de wetenschap. De Universiteit Leiden is een kennis- en expertisecentrum van data science dat de nadruk legt op interdisciplinaire samenwerking en innovatie.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Remus Dame

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.