Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Fate and toxicity of copper nanoparticles was related to the water chemistry of the environment and pristine size.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Promotor: M.A.G.J. Orrit

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. It is the main cause of birch pollen allergy in humans.

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This thesis describes a study from both a theoreticaL and an experimental point of view.

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Promotor: Prof.dr. J.W.M. Frenken

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?

Promotor: A. Kros

Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Hoe kan de methode om de gecombineerde effecten van metaal-gebaseerde chemische stoffetn te bepalen worden verbeterd?

Promotor: W. Jiskoot, Co-promotor: A. Kros

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Promotores: W. Jiskoot, F. Ossendorp

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

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Promotores: Wim Jiskoot; Ferry Ossendorp

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Individuele moleculen zijn extreem moeilijk te zien via hun zwakke fluorescentie. Piepkleine gouden nanostaafjes fungeren als nieuwe antennes om hun signaal 500 maal te versterken. Publicatie op 24 februari in Angewandte Chemie.

Nanoplastics beïnvloeden het gedrag van zebravislarven, blijkt uit onderzoek van Instituut Biologie Leiden (IBL) en het Centrum voor Milieuwetenschappen Leiden (CML). De onderzoekers zagen dat een bepaald type nanodeeltjes leidt tot stressreacties in de suikerhuishouding, met als gevolg hyperactiviteit…

In hoeverre hopen nanodeeltjes zich op in planten en dieren, en welke eigenschappen van de deeltjes spelen hierbij een rol? Willie Peijnenburg, hoogleraar Milieutoxicologie en biodiversiteit kreeg een Marie-Curie beurs toegekend om onderzoek te doen naar de milieueffecten van nanodeeltjes.

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Moleculen detecteren met temperatuur in plaats van chemische reacties: dat is wat wetenschappers van het Leids Instituut voor Onderzoek in de Natuurkunde willen doen. Ze ontwikkelen een sensor die speciale nanodeeltjes gebruikt om moleculen in de gaten te houden. Op deze manier kunnen ze bijvoorbeeld…

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Wat zijn de risico's van nanodeeltjes?

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Heterogeneous catalysis is essential to many industrial applications. These catalysts are often comprised of supported nanoparticles, which contain various different surface sites.