120 zoekresultaten voor “multi-objective optimization” in de Publieke website
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Meta-heuristics for vehicle routing and inventory routing problems
Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich
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Optimization and Application of 3D Reconstruction for Optical Projection Tomography
Promotie
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Stochastic and Deterministic Algorithms for Continuous Black-Box Optimization
Promotie
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weighted ensembles of surrogate models for sequential parameter optimization
Promotie
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Morphogenesis and protein production in Aspergillus niger
Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram
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Detection of Dynamic Communities in Social Networks through the use of Multi-Objective Genetic Algorithms
Lezing
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Algoritme Data Science-student ontwerpt beste schip in minder tijd
Mede dankzij Roy de Winter ontwikkelt scheepsontwerp- en ingenieursbureau C-Job Naval Architects in korte tijd optimale schepen. De masterstudent Computer Science in Leiden ontwikkelde namelijk het algoritme CEGO, dat de klassieke ontwerpcyclus doorbreekt en de mens in het maritiem optimalisatietraject…
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Optimization of secondary prevention and risk stratification in patients with coronary heart disease
Promotie
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Self-Adjusting Surrogate-Assisted Optimization Techniques for Expensive Constrained Black Box Problems
Promotie
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Optimization of suntinib treatment in metastatic renal cell carcinoma: pharmacogenetic evidence and challenges
Promotie
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Promotie
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Generalized Strictly Periodic Scheduling Analysis, Resource Optimization, and Implementation of Adaptive Streaming Applications
Promotie
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Lab-on-a-tissue: Optimization of On-Tissue Chemistry for Improved Mass Spectrometry Imaging
Promotie
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Representations of High-dimensional CAE Models for Automotive Design Optimization
Promotie
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Biophysical characterization of membrane protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink
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Ecological functions and environmental fate of exopolymers of Acidobacteria
Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.
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The electrode-electrolyte interface in CO2 reduction and H2 evolution: a multiscale approach
Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Improving robustness of tomographic reconstruction methods
Promotor: Prof.dr. K.J. Batenburg
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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Constraint-Based Analysis of Business Process Models
Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.
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Wiskunde en Natuurwetenschappen
Het onderzoek binnen de Faculteit der Wiskunde en Natuurwetenschappen omvat de disciplines wiskunde, informatica, sterrenkunde, natuurkunde, scheikunde, bio-farmaceutische wetenschappen, biologie en milieuwetenschappen.
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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Improved Strategies for Distance Based Clustering of Objects on Subsets of Attributes in High-Dimensional Data
This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.
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Biodiesel production using blue-green cyanobacterium Synechococcus elongatus PCC 7942
Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination
CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…
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This Week's Discoveries | 16 april 2019
Lezing
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Joint Lectures on Evolutionary Algorithms (JoLEA)
Lezing
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Multiple-criteria landscapes with valleys and hills
Computer scientists from Leiden University and the University of Münster describe a new theoretical starting point for approaching difficult optimization problems. They can take into account several criteria simultaneously, instead of just one at a time.
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Pascal Professor 2012
In 2012 the Pascal chair of the Faculty of Science of Leiden University, and particular of Leiden Institute of Advanced Computer Science (LIACS), will be held by Prof. Dr. Kyle Gallivan, Department of Mathematics, Florida State University, USA.
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Kunstmatige intelligentie en machine learning
Computers zijn in staat om ongelooflijk nauwkeurige voorspellingen te doen op basis van machine learning. Met andere woorden, deze computers kunnen zonder tussenkomst leren als ze eenmaal door mensen zijn voorgeprogrammeerd. Bij LIACS verkennen en verleggen we de grenzen van wat een revolutionaire nieuwe…
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Promotie
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Algorithms help improve building design
Modern optimization algorithms offer solutions for architectural decisions like spatial, structural and energy efficiency. A young computer scientist from Leiden University co-authored a paper that won the Best Paper Award at a leading conference in Krakow during the summer.
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Freek Janssen wint KNCV Farmacochemie prijs voor beste presentatie
Freek Janssen kreeg tijdens de FIGON Dutch Medicine Days 2015 op 5 oktober in Ede de KNCV Farmacochemie prijs voor beste presentatie uitgereikt. Janssen ontvangt deze prijs voor zijn presentatie
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Dr. Charlene Kalle and Dr. Tim van Erven awarded with TOP-grant
Dr. Charlene Kalle and dr. Tim van Erven, both assistant professors at the Mathematical Institute of Leiden University have received a TOP grant for Physical Sciences from the NWO (The Netherlands Organization for Scientific Research).
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PHD candidate/graduate student in dynamical systems
Wiskunde en Natuurwetenschappen, Mathematisch Instituut (MI)
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CECILIA2050 - Optimal EU climate policy
Development of scenarios for 2050 detailed in an IO framework
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Assistant Professor: Computational Modelling in Translational Metabolomics (1.0 fte)
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Afkijken bij de natuur
Een neuraal netwerk imiteert de werking van onze hersenen. Evolutionaire algoritmes gebruiken het principe van natuurlijke selectie om een complex probleem op te lossen. Deze vormen van natural computing worden ingezet om de diagnose van de ziekte van Parkinson accurater te maken, maar ook om bijvoorbeeld…
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Top-subsidie voor 4 Leidse exacte topwetenschappers
Maar liefst vier wetenschappers ontvangen een TOP-subsidie Exacte Wetenschappen van NWO. Het gaat om astronoom Ignas Snellen, wiskundigen Tim van Erven en Charlene Kalle en informaticus Siegfried Nijssen. Met het geld worden tijdelijke onderzoeksposities gefinancierd.
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LIACS receives NWO grant in Challenging Big Data program
The Leiden Institute of Advanced Computer Science (LIACS) received a grant award from NWO for a joint proposal with Centrum Wiskunde & Informatica (CWI, Amsterdam), Tata Steel (IJmuiden), BMW (Munich), and database company MonetDB. Within the NWO Data Science program ‘challenging big data‘, LIACS is…
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Zes Leidse informaticastudenten blinken uit en mogen naar Oxford
Zes masterstudenten van de opleiding Informatica mogen hun papers over toekomstige steden presenteren bij de NetMob conferentie in Oxford. De zes papers waren onderdeel van de internationale Future Cities Challenge en haalden de top 10 van alle inzendingen.
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Kunstmatige intelligentie en machine learning
Computers zijn in staat om ongelooflijk nauwkeurige voorspellingen te doen op basis van machine learning. Met andere woorden, deze computers kunnen zonder tussenkomst leren als ze eenmaal door mensen zijn voorgeprogrammeerd. Bij LIACS verkennen en verleggen we de grenzen van wat een revolutionaire nieuwe…
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PhD candidate for the project “Inflammatory mechanisms of atherosclerosis and its therapeutic potential”
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)