426 zoekresultaten voor “molecular scatology” in de Publieke website
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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Evolutionary diversification of Nepenthes (Nepenthaceae)
Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes
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Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B
Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.
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Control of Western flower thrips through jasmonate-triggered plant immunity
We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.
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Synthetic peptides as tools in chemical immunology
This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.
- Agenda bachelor
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Convergent molecular evolution of toxins in the venom of advanced snakes (Colubroidea)
Promotie
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The electrochemical reduction of dioxygen and hydrogen peroxide by molecular copper catalysts
Promotie
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Mechanistic studies of the water oxidation reaction with molecular iron catalysts
Promotie
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Molecular pathology in bone and soft tissue tumors: A multifunctional key for diagnosis and prediction
Promotie
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Outcome of osteoarthritis and arthroplasty: from patient perspective to molecular profiling
Promotie
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Synthetic peptides, nucleic acids and molecular probes to study ADP- ribosylation
Promotie
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Manipulating endosomal systems: the molecular mechanism of transport decisions and Salmonella-induced cancer
Promotie
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Molecular pathways involved in renal injury-repair and ADPKD progression
Promotie
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Elucidation of the molecular alterations underlying aging-associated muscle wasting by applying multi-omics
Promotie
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Molecular and Nano-Engineering with Iron, Ruthenium and Carbon: Hybrid structures for Sensing
Promotie
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Towards Photocatalytic Water Splitting in Homogeneous Solutions Using Molecular Metalloporphyrin Photosensitizers and Catalysts
Promotie
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Ziektes detecteren met moleculen in het lichaam
Is het mogelijk om ziektes te diagnosticeren met behulp van moleculaire schakelaars? Over die vraag buigt het nieuwe internationale consortium LogicLab zich. Vanuit Leiden zijn scheikundige Sylvestre Bonnet en farmacoloog Thomas Hankemeier betrokken. Het project loopt voor vier jaar en krijgt ruim 3,5…
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FRESH Lecture: Observation of long-lived molecular vibrations during adsorption and desorption on a metal surface
Lezing
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Molecular pathology of hereditary cerebral hemorrhage with amyloidosis-Dutch type
Promotie
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Molecular and genetic markers for the prediction of kidney transplant outcome
Promotie
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Contact
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Group benefits from genomic instability: a tale of antibiotic warriors in Streptomyces
Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.
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Arbeidsmarkt
Na de master kiezen de meeste alumni voor een baan in het bedrijfsleven of bij de overheid.
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Topology and Geometry in Chiral Liquids
We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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Self-Steering Committees
Binnen Una Europa vindt academische samenwerking plaats in interdisciplinaire zelfsturende comités (SSC’s).
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Vervolgopleidingen
Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding. De Universiteit Leiden stimuleert studenten om na hun bacheloropleiding door te gaan met de masteropleiding.
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Bestuur
Het Natuurwetenschappelijk Gezelschap Leiden heeft haar succes mede te danken aan de diverse besturen die de lezingen, vergaderingen en activiteiten van het gezelschap hebben verzorgd.
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Linking simple molecules to grain evolution across planet-forming disks
Planets are formed in disks of gas and dust around young stars.
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Studies of dust and gas in the interstellar medium of the Milky Way
Promotor: Prof.dr. A.G.G.M. Tielens
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Integrative taxonomy of araneomorph spiders: Breathing new life into an old science
Taxonomy as a science has accumulated data and knowledge for more than 250 years.
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Multiple star formation: chemistry, physics and coevality
Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.
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Supramolecular polymer materials for biomedical applications and diagnostics
Self-assembly is an abundant process in nature and is vital to many processes in living organisms.
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How Electrostatic Interactions Drive Nucleosome Binding of RNF168 & PSIP1
The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.
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Rationally designed peptide based functional biomaterials
Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Targeting the adenosinergic system
Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Plasmonic enhancement of single-molecule fluorescence under one- and two-photon excitation
This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…
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Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)
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Volatile compounds from Actinobacteria as mediators of microbial interactions
Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.
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Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Analysis of the angucycline biosynthetic gene cluster in Streptomyces sp. QL37 and implications for lugdunomycin production
Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.
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Tracing the journey of the sun and the solar siblings through the Milky Way
Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown