Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Tijdens de studie Molecular Science & Technology leren studenten te werken aan schonere en efficiëntere processen en worden zij opgeleid om nieuwe technologieën te ontwikkelen als antwoord op de uitdagingen van de toekomst: de groeiende vraag naar nieuwe producten en milieuvriendelijke processen. Bij…

Bij de bacheloropleiding Molecular Science & Technology aan de Universiteit Leiden ontwikkelen studenten een sterke theoretische basis in de scheikunde en doen ze kennis van de technologische toepassingen op. Daarnaast leren studenten een bijdrage te leveren aan vraagstukken op het gebied van duurzaamheid,…

Deze opleiding integreert genetica, moleculaire biologie en biotechnologie in een aantrekkelijk programma met uitstekende carrièreperspectieven.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Ingen

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Promotor: Prof.dr. G.J. Kroes

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

Promotor: J. A. Bouwstra

Promotor: Prof.dr. J. den Hertog

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Kros

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

The space between the stars isn't simply a void; it also contains substances such as methanol and carbon dioxide. So far, chemical theories have been unable to explain how these substances originate under circumstances that should make it impossible. Fedor Goumans has been awarded a Veni subsidy to…

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Laboratory, observation and modeling work on the dissociation of polycyclic aromatic hydrocarbons in interstellar environments and the formation of new molecular species through the fragmentation process.