... which focuses on the development and use of new multivariate statistical tools needed for analyses of data collected in the four other programs.

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

D1.2 reports on the findings of an analysis of framework conditions relevant in the context of the data economy from a legal, a socio-economic and a technological perspective. The analysis is a key foundation for the creation of an initial, heuristic model of the European data economy. The deliverable…

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

De masteropleiding Cultural Analysis: Literature and Theory van de Universiteit Leiden richt zich op de studie van literatuur vanuit een vergelijkend en theoretisch perspectief, en onderzoekt de literatuur van een breed spectrum van talen en culturen uit de hele wereld.

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Analytical tools for environmental design and management in a systems perspective. The combined use of analytical tools.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Promotor: Roeland M.H. Merks

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Peter Grunwald

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Sociale Wetenschappen, Culturele Antropologie en Ontwikkelingssociologie

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Co-ordination Action for Innovation in Life-Cycle Analysis for Sustainability: deepening, broadening and leaping forward the LCA methodology.

Promotor: Prof. dr. A.G.G.M. Tielens

Description of Triple bottom line approach for risk-benefit analysis of genetically modified crops.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Fokelien Kootstra verdedigde haar proefschrift op 23 april 2019

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Netherlands Statistics (CBS), Leiden University and the University of Amsterdam have started a collaboration in the form of a research project titled 'Enriching official economic statistics using data-driven modelling techniques'.

The global agri-food system plays a critical role in food security and environmental issues.

Hoe moet de EU omgaan met Oekraïne, Wit-Rusland en Moldavië? Hoe kunnen we de Europese Unie helpen om, in een uiterst moeilijke en veeleisende geopolitieke context, zijn politiek ten aanzien van deze landen te heroverwegen?

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?

Promotie