Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Promotor: Prof.dr. E. Deprettere

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

This thesis is based on five papers on several topics.

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

... which focuses on the development and use of new multivariate statistical tools needed for analyses of data collected in the four other programs.

D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Het onderzoek van dit programma is gecentreerd rond dynamische systemen, functionele analyse en hun interactie.

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

D1.2 reports on the findings of an analysis of framework conditions relevant in the context of the data economy from a legal, a socio-economic and a technological perspective. The analysis is a key foundation for the creation of an initial, heuristic model of the European data economy. The deliverable…

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Wiskunde en Natuurwetenschappen, Mathematisch Instituut (MI)

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

De masteropleiding Cultural Analysis: Literature and Theory van de Universiteit Leiden richt zich op de studie van literatuur vanuit een vergelijkend en theoretisch perspectief, en onderzoekt de literatuur van een breed spectrum van talen en culturen uit de hele wereld.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Can we develop a platform for raw materials intelligence?

Analytical tools for environmental design and management in a systems perspective. The combined use of analytical tools.

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

With the emergence of online social networks (OSNs), the way people create and share information has changed, which becomes faster and broader than traditional social media.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

This thesis focuses on addressing four research problems in designing embedded streaming systems.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Promotor: Prof.dr. B. van de Water

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Promotor: Roeland M.H. Merks

... which builds on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.

Een nieuwe infrastructuur voor onderzoeksdata in computationele sociale wetenschappen

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Kunst en vrije tijd, Kunst en vrije tijd

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.