What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…

Promotores: J.N. Kok, H.J. Hoogeboom

DNA-onderzoek is veel minder hard dan altijd werd gedacht, zo blijkt uit artikelen in het Forensic Science International: Genetics en het Nederlands Juristenblad.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Onze DNA-moleculen worden door eiwitten verpakt in compacte structuren. Het doel van dit project is om te begrijpen hoe moderne technieken voor genbewerking desalniettemin toegang krijgen tot hun doelwit op het DNA.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Promotor: R.D. Gill, F. Taroni

Het onderzoek van dit programma is gecentreerd rond dynamische systemen, functionele analyse en hun interactie.

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

Supervisor: P.J.J. Hooykaas

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

De masteropleiding Cultural Analysis: Literature and Theory van de Universiteit Leiden richt zich op de studie van literatuur vanuit een vergelijkend en theoretisch perspectief, en onderzoekt de literatuur van een breed spectrum van talen en culturen uit de hele wereld.

This thesis is based on five papers on several topics.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Promotor: Prof.dr. E. Deprettere

Migratie is diep verankerd in het DNA van Amsterdam.

Can we develop a platform for raw materials intelligence?

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

Hoe kun je tumorcellen zo effectief mogelijk uitschakelen? Het DNA-reparatiemechanisme lijkt een belangrijk mechanisme om de effectiviteit van de bestrijding van kankercellen met chemotherapie te vergroten. Om dit mechanisme te beïnvloeden is fundamentele kennis over de werking van het DNA-reparatiemechanisme…

Promotor: Prof.dr. B. van de Water

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

D1.2 reports on the findings of an analysis of framework conditions relevant in the context of the data economy from a legal, a socio-economic and a technological perspective. The analysis is a key foundation for the creation of an initial, heuristic model of the European data economy. The deliverable…

Een infrastructuur voor onderzoeksdata in computationele sociale wetenschappen

Analytical tools for environmental design and management in a systems perspective. The combined use of analytical tools.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Sommige mensen van hoge leeftijd blijken DNA te hebben waarvan de afstelling nauwelijks verouderd is. Dat schrijven onderzoekers onder leiding van Bas Heijmans van het LUMC in het wetenschappelijke tijdschrift Genome Biology.

Eencellige organismen hebben stijver DNA dan meercellige levensvormen zoals mensen en rijst. Theoretisch natuurkundigen komen tot deze conclusie na simulatie van buiging in volledige genomen. Publicatie in Biophysical Journal op 7 februari.

Promotor: S.M. Verduyn Lunel

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

De Leidse natuurkundige Maarten Kruithof heeft ontdekt hoe ons DNA zich telkens weer feilloos weet op te vouwen en ook weer weet te ontvouwen. In zijn proefschrift toonde hij aan dat het DNA opgevouwen wordt in één lange, zeer flexibele spiraalvorm.

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Co-ordination Action for Innovation in Life-Cycle Analysis for Sustainability: deepening, broadening and leaping forward the LCA methodology.

Promotie