125 zoekresultaten voor “metabolomics” in de Publieke website
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Metabolomics Faciliteit
We leveren fenotypische read- outs voor diagnose en patiënt stratificatie voor een behandeling op basis van innovatieve metabolomics, UPE en organ-on-a-chip technologie. Met een farmacologische én biologische aanpak bieden we inzicht in ziektemechanismen en vertalen dat voor de gepersonaliseerde gen…
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BioMedical Metabolomics Facility Leiden
De BioMedical Metabolomics Facility Leiden (BMFL) biedt een zeer gestructureerde omgeving voor geavanceerd metobolomicsonderzoek. BMFL is gebaseerd op volledig gevalideerde, moderne platforms die gezamenlijk het gehele menselijke metabolisme beslaan.
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Postdoc, (Metabolomics LED-light-grown plants)
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
- Centrum voor Proteomics en Metabolomics
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Postdoctoral Researcher Chiral Metabolomics (0.8 fte)
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Exploration of the endocannabinoid system using metabolomics
Promotie
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Quantification in untargeted mass spectrometry-based metabolomics
Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers
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Metabolomic characteristics of Catharanthus roseus plants in time and space
Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa
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CE-MS for metabolomics: advancing performance and detection sensitivity
The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.
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High-throughput quantification and unambiguous identification for metabolomics
The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
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Assistant Professor: Metabolomics & Novel technologies (1.0 fte)
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Thrips resistance in Gladiolus: an eco-metabolomic approach
Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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Non-target effects of GM potato: an eco-metabolomics approach
Promotores: P.G.L. Klinkhamer, P.M. Brakefield, Co-Promotor: M. Bruinsma
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Metabolomic characterization of plant exudates and their correlation with plant defense systems
Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
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Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken
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From the root of variation: A metabolomics perspective to plant soil-feedback
By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.
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Postdoctoral Researcher: Robotics and Automation for High Throughput Metabolomics (1.0 FTE
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Postdoctoral Researcher: Robotics and Automation for High Throughput Metabolomics (1.0 FTE
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Onderzoeken van een nieuwe volume-aanpak in metabolomics met capillaire elektroforese-massaspectrometrie
Ramautar
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whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based metabolomics approach
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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Beter, sneller en vroeger diagnose met de nieuwe Metabolomics Faciliteit
Op vrijdag 17 april opent de burgemeester van Leiden, de heer Lenferink, de Metabolomics Faciliteit van de Universiteit Leiden. Metabolomics onderzoek maakt veranderingen in de stofwisseling zichtbaar waardoor in de toekomst een diagnose beter, sneller en vroeger kan worden gesteld en het effect van…
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Harvesting sunlight with plants and microorganisms: imaging and metabolomics with novel microcoil and cryoprobe at ultrahigh magnetic field
Huub de Groot
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Metabolomics Implementation Network gelanceerd voor eerlijke data
Op 10 maart 2017 verwelkomde Professor Karel Luyben (TU Delft) het Metabolomics GO FAIR Implementation Network als community initiatief om de Europese Open Science Cloud te starten. Het netwerk richt zich op het implementeren van de FAIR data principes binnen metabolomics in Europa.
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C2W: Thomas Hankemeier boegbeeld van metabolomics in Nederland
C2W interviewde analytisch biochemicus Thomas Hankemeier over dertien jaar hoogleraarschap in Leiden. Hij is hét boegbeeld voor het metabolomicsveld in Nederland geworden, aldus het vakblad.
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Modulation of plant chemistry by rhizosphere bacteria
Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.
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‘Samenwerking metabolomics in fieldlab Phenomix brengt de praktijk naar de universiteit’
Op 9 juli openende het nieuwe Medical Delta Fieldlab Phenomix haar deuren. In het fieldlab werken wetenschappers, zorginstellingen en bedrijven samen praktische toepassingen van metabolomics-onderzoek: onderzoek naar stofwisselingsproducten. Medical Delta sprak met de Leidse hoogleraar Thomas Hankemeier.…
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Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
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Control of Western flower thrips through jasmonate-triggered plant immunity
We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.
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Factors affecting galanthamine production in Narcissus
Factors affecting galanthamine production in Narcissus
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Metabolic signatures in nutrition and health: short-term diet response, sexual dimorphism and hormone chronobiology
The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).
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Natali Rianika MustafaWiskunde en Natuurwetenschappen
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Towards automated identification of metabolites using mass spectral trees
Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers
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Terpenoids and terpenoid indole alkaloids in Catharanthus roseus cell suspension cultures
Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte
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Giant barrel sponges in diverse habitats: a story about the metabolome
Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.
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Functions of leptin in tuberculosis and diabetes: multi-omics studies across species
In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.
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Robert VerpoorteWiskunde en Natuurwetenschappen
- Onderzoeksfaciliteiten
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Postdoctoral Researcher: Rapid MS-detection and characterization of variants of viral infections (1.0 fte)
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Postdoctoral Researcher: Rapid MS-detection and characterization of variants of viral infections (1.0 fte)
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi
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Comprehensive metabolomics of the experimental opisthorchiasis
Promotie
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De interpretatie van wearable gegevens over lichaamsbeweging en de relatie met metabolisme en hersengezondheid bij oudere volwassenen
Het kwantificeren van lichamelijke activiteit (met behulp van versnellingsmeters) en het combineren van de frequentie en intensiteit van activiteiten met gezondheidsgegevens (hersen-MRI, traditionele klinische parameters en metabolomics) is van het grootste belang om mobiliteit en gezondheid bij oudere…
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.