This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Promotor: A.W. van der Vaart

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Het onderzoeksprogramma Statistical Science houdt zich bezig met de analyse en interpretatie van grote hoeveelheden data, de kwantificering van onzekerheid met behulp van kansmodellen en de ontwikkeling en benchmarking van algoritmen en methoden gericht op dataonderzoek.

Promotores: J.C. van Houwelingen, S.A. van de Geer

Promotor: R.D. Gill, F. Taroni

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Wiskunde en Natuurwetenschappen, Mathematisch Instituut (MI)

Wiskunde en Natuurwetenschappen, Mathematisch Instituut (MI)

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

This thesis develops statistical methods for the analysis of high dimensional data: high dimensional networks reconstruction (Chapters 1-4), incorporation of prior information in networks reconstruction (Chapters 2-4), incorporation of prior knowledge in genetic association studies (Chapter 3).

Promotor: Prof.dr. E. Deprettere

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Promotor: Prof. dr. A.G.G.M. Tielens

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Promotor: Prof.dr. F. den Hollander, G.Maillard

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

Promotor: P.D. Grünwald

Promotor: Prof.dr. J.N. Kok

In this thesis,

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Promotor: Roeland M.H. Merks

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Promotores: J. Kok, M. Chaudron (Chalmers University)

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

... which builds on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Promotor: S.M. Verduyn Lunel

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Op 6 juni 2019 verdedigde Edward Donelan zijn proefschrift 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. Het promotieonderzoek is begeleid door promotor prof. W.J.M. Voermans.

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)