4,802 zoekresultaten voor “mathematical and statistical modelling” in de Publieke website
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Statistical modelling of time-varying covariates for survival data
This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.
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Statistical physics and information theory for systems with local constraints
Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.
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Topics in mathematical and applied statistics
Promotor: A.W. van der Vaart
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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PHD candidate, Mathematical modeling for prediction of liver toxicity
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Statistical Science
Het onderzoeksprogramma Statistical Science houdt zich bezig met de analyse en interpretatie van grote hoeveelheden data, de kwantificering van onzekerheid met behulp van kansmodellen en de ontwikkeling en benchmarking van algoritmen en methoden gericht op dataonderzoek.
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Statistical methods for microarray data
Promotores: J.C. van Houwelingen, S.A. van de Geer
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Current challenges in statistical DNA evidence evaluation
Promotor: R.D. Gill, F. Taroni
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Multiscale mathematical biology of cell-extracellular matrix interactions during morphogenesis
During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.
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Scientific Director of the Mathematical Institute
Wiskunde en Natuurwetenschappen, Mathematisch Instituut (MI)
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Tenure Track Assistant or Associate professor in Mathematical Statistics
Wiskunde en Natuurwetenschappen, Mathematisch Instituut (MI)
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Abstract Behavioral Specification: unifying modeling and programming
We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.
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Postdoc in the field of mathematical biophysics (polymer topology)
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Prior information and variational Bayes in high dimensional statistical network inference
This thesis develops statistical methods for the analysis of high dimensional data: high dimensional networks reconstruction (Chapters 1-4), incorporation of prior information in networks reconstruction (Chapters 2-4), incorporation of prior knowledge in genetic association studies (Chapter 3).
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Adaptive Streaming Applications: Analysis and Implementation Models
Promotor: Prof.dr. E. Deprettere
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Bayesian Inference for Gaussian Models
This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.
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Biological model representation and analysis
Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek
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Duality, bosonic particle systems and some exactly solvable models of non-equilibrium
Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander
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Computational modeling of cellular dynamics in tumor cell migration
Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.
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On metrics and models for multiplex networks
In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Abstract delta modeling: software product lines and beyond
Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke
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Modelling the role of cytotoxic T lymphocytes in tumour regression
Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.
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Modeling interstellar bubbles: near and far
Promotor: Prof. dr. A.G.G.M. Tielens
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.
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The parabolic Anderson model and long-range percolation
Promotor: Prof.dr. F. den Hollander, G.Maillard
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Lattice models for Josephson junctions and graphene superlattices
In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.
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Personalised medicine for multiple outcomes: methods and application
The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.
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Better Predictions when Models are Wrong or Underspecified
Promotor: P.D. Grünwald
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Computational modeling of mycobacterium infection and innate immune reponse in zebrafish
Promotor: Prof.dr. J.N. Kok
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Empirical signatures of universality, hierarchy and clustering in culture
In this thesis,
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Computational modeling of angiogenesis : from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
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Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
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An Online Corpus of UML design models: Construction and empirical studies
Promotores: J. Kok, M. Chaudron (Chalmers University)
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Biotic ligand models
Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)
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Gibbs Processes and Applications
Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.
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Self-regulation models
... which builds on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Stochastic resetting and hierarchical synchronisation
Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.
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Pharmacogenomics in Drug Development: Implementation and Application of PKPD Model Based Approaches
Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
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Néron models in high dimension: nodal curves, Jacobians and tame base change
We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.
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PHD candidate, Computational modelling for drug safety prediction
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Assistant professor Statistics and Pharmacometrics
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation
Op 6 juni 2019 verdedigde Edward Donelan zijn proefschrift 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. Het promotieonderzoek is begeleid door promotor prof. W.J.M. Voermans.
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signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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PhD in Quantitative Cell and Developmental Biology
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)