207 zoekresultaten voor “mass spectrometry” in de Publieke website
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Technician Mass Spectrometry
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Postdoc candidate in analytical chemistry / mass spectrometry / proteomics
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Quantification in untargeted mass spectrometry-based metabolomics
Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers
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Towards automated identification of metabolites using mass spectral trees
Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken
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Glycosylation profiling with mass spectrometry
Promotie
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The early stress response of jasmonic acid in cell suspension cultures of Catharanthus roseus
In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…
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Deciphering the Ubiquitin Code by Mass Spectrometry
Promotie
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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The puzzle of protoplanetary disk masses
My work focuses on a class of astronomical objects called protoplanetary disks.
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High-throughput quantification and unambiguous identification for metabolomics
The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.
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Clinical Glycomics of Antibodies by Mass Spectrometry
Promotie
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Unveiling protostellar disk formation around low-mass stars
Promotor: Prof.dr. E.F. van Dishoeck
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The connection between mass and light in galaxy clusters
Promotor: Koen Kuijken Co-promotor: Henk Hoekstra
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
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Unraveling proteoform complexity by native Liquid chromatography - mass spectrometry
Promotie
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The distribution of stellar mass in galaxy clusters over cosmic time
Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra
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Deep: Using simulations to understand the excess baryonic mass in the centres of high-mass, early-type galaxies
This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…
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Towards photo-CIDNP MAS NMR as a generally applicable enhancement method
Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)
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Boosting mass spectrometry-based analytics for biopharma
Promotie
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Some Assembly Required: The Structural Evolution and Mass Assembly of Galaxies at z
This thesis investigates the structural evolution and assembly of galaxies since the first few billions years after the big bang.
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Statistical Methods for Mass Spectrometry-based Clinical Proteomics
Promotie
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
Promotie
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Feedback from deeply embedded low- and high-mass protostars. Surveying hot molecular gas with Herschel
Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg
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and functional characterization of therapeutic glycoproteins by mass spectrometry
Promotie
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Tenure Track Assistant or Associate Professor
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Lab-on-a-tissue: Optimization of On-Tissue Chemistry for Improved Mass Spectrometry Imaging
Promotie
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Postdoctoral Researcher Chiral Metabolomics (0.8 fte)
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based metabolomics approach
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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Understanding disease suppressive soils
Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Exploration of the endocannabinoid system using metabolomics
Promotie
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Intelligent Workflows for Automated Analysis of Mass Spectrometry- based Proteomics Data
Promotie
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structural study of light-harvesting complexes : an investigation with MAS-NMR
Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.
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Paving the path between low- and high-mass star formation: dynamics probed by Herschel far-infrared spectroscopy
Promotor: Prof.dr. E.F. van Dishoeck, Prof.dr. F.F.S. van der Tak (RUG)
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Monitoring and detection of nanomaterials in biological media.
How do nanoparticles bioaccumulate and biodistribute in organisms?
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Tuning in to star-planet interactions at radio wavelengths
Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.
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The Great Collapse
Promotor: Prof.dr. S.F. Portegies Zwart
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The Masses and the Muses, transformatie van Teylers Museum
Aan het einde van de achttiende en het begin van de negentiende eeuw was Teylers Museum het belangrijkste onderzoeksinstituut van ons land voor kunsten en wetenschappen. In de twintigste eeuw werd zelfs ‘s werelds meest toonaangevende fysicus, de Leidse hoogleraar Hendrik Antoon Lorentz aangetrokken.…
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Postdoctoral Researcher: Robotics and Automation for High Throughput Metabolomics (1.0 FTE
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Postdoctoral Researcher: Rapid MS-detection and characterization of variants of viral infections (1.0 fte)
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Postdoctoral Researcher: Rapid MS-detection and characterization of variants of viral infections (1.0 fte)
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Postdoctoral Researcher: Robotics and Automation for High Throughput Metabolomics (1.0 FTE
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)