154 zoekresultaten voor “mass spectrometry” in de Publieke website
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Technician Mass Spectrometry
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Postdoc candidate in analytical chemistry / mass spectrometry / proteomics
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Quantification in untargeted mass spectrometry-based metabolomics
Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers
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Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Mass spectrometry based protein profiling
Promotie
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The early stress response of jasmonic acid in cell suspension cultures of Catharanthus roseus
In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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The puzzle of protoplanetary disk masses
My work focuses on a class of astronomical objects called protoplanetary disks.
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High-throughput quantification and unambiguous identification for metabolomics
The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.
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Unveiling protostellar disk formation around low-mass stars
Promotor: Prof.dr. E.F. van Dishoeck
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Biomarker Discovery in High Grade Sarcomas by Mass Spectrometry Imaging
Promotie
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The connection between mass and light in galaxy clusters
Promotor: Koen Kuijken Co-promotor: Henk Hoekstra
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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The distribution of stellar mass in galaxy clusters over cosmic time
Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra
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Towards photo-CIDNP MAS NMR as a generally applicable enhancement method
Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)
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Boosting mass spectrometry-based analytics for biopharma
Promotie
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Statistical Methods for Mass Spectrometry-based Clinical Proteomics
Promotie
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
Promotie
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Some Assembly Required: The Structural Evolution and Mass Assembly of Galaxies at z
This thesis investigates the structural evolution and assembly of galaxies since the first few billions years after the big bang.
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Feedback from deeply embedded low- and high-mass protostars. Surveying hot molecular gas with Herschel
Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg
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and functional characterization of therapeutic glycoproteins by mass spectrometry
Promotie
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Lab-on-a-tissue: Optimization of On-Tissue Chemistry for Improved Mass Spectrometry Imaging
Promotie
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Tenure Track Assistant or Associate Professor
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Intelligent Workflows for Automated Analysis of Mass Spectrometry- based Proteomics Data
Promotie
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Understanding disease suppressive soils
Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.
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structural study of light-harvesting complexes : an investigation with MAS-NMR
Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.
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Paving the path between low- and high-mass star formation: dynamics probed by Herschel far-infrared spectroscopy
Promotor: Prof.dr. E.F. van Dishoeck, Prof.dr. F.F.S. van der Tak (RUG)
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Monitoring and detection of nanomaterials in biological media.
How do nanoparticles bioaccumulate and biodistribute in organisms?
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The astrochemical factory: A solid base for interstellar reactions
In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.
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Postdoc candidate in biochemistry / cell glycobiology / protein targeted degradation
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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2 PhD candidates to study the molecular mechanisms of the Hsp70 chaperone in neurodegenerative disease
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Postdoc, (Metabolomics LED-light-grown plants)
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
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Postdoc, (Unlocking Nature’s Pharmacy from Bogland Species)
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
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Multiple star formation: chemistry, physics and coevality
Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.
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Speckmann prijs 2022 voor Simay Çetin, Nova Folkersma, Marta Mas Castella, Iris Molenaar en Emma van der Plas
Alumna Simay Çetin heeft de Speckmann prijs gewonnen voor haar masterscriptie 'Interpreting Culture through Embodied Practice: An anthropological study of sexuality between Dutch Women with Turkish Migrant backgrounds'. Nova Folkersma, Marta Mas Castella, Iris Molenaar and Emma van der Plas kregen de…
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Vier Rubicons naar Leiden
De tweede toekenningsronde van de Rubiconsubsidies heeft vier gehonoreerde onderzoeksprojecten opgeleverd voor de Universiteit Leiden. Drie jonge Leidse wetenschappers mogen onderzoek doen aan prestigieuze onderzoeksinstellingen in het buitenland en één onderzoeker komt naar Leiden toe.
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Fully funded Ph.D. position – combinatorial drug discovery
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR), LACDR PhD Portal
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The interplay between stars, gas and dust in faint star-forming galaxies
When observing star-forming galaxies, we are not only seeing stellar light, but we also see how this interacts with galactic gas and dust. This thesis contains studies of the stellar, nebular and dust properties of low mass star-forming galaxies.
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Modeling interstellar bubbles: near and far
Promotor: Prof. dr. A.G.G.M. Tielens
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Young suns and infant planets: Probing the origins of solar systems
Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).
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Studying dark matter using weak gravitational lensing : from galaxies to the cosmic web
Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).
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The origins of friction and the growth of graphene, investigated at the atomic scale
Promotor: J.W.M. Frenken
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Sterile neutrinos in the early Universe
Promotor: A. Achúcarro, Co-promotor: A. Boyarsky