22 zoekresultaten voor “macrophages” in de Publieke website
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Macrophage activation and cholesterol in atherosclerosis development
Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…
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Macrophage activation and cholesterol in atherosclerosis development
Promotores:Th.J.C. van Berkel, M. van Eck
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination
CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…
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Selective autophagy in host defense against mycobacterial infection
The effective treatment of tuberculosis (TB) remains a major challenge to global health.
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Key innate immune components controlling intracellular infection
Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Targeting macrophages in renal transplantation
Promotie
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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The synthesis of mannose-derived bioconjugates and enzyme inhibitors
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee
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Chemokine signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Investigations on the role of impaired lysosomes of macrophages in disease
Promotie
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Hoe reageert de afweer op overgewicht?
Ons afweersysteem reageert slecht op vetcellen, wat de kans op diabetes type 2 vergroot. Maar ook is onze afweer misschien juist in te zetten als bescherming tegen diabetes. Onderzoekers gaan ermee aan de slag, met steun van het Diabetes Fonds.
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Verstoorde beweging maakt macrofagen dodelijker voor tuberculosebacteriën
Macrofagen – de frontlinie van ons afweersysteem – beschermen ons tegen infecties. Maar bij de tuberculosebacterie gaat dat vaak mis. De groep van Annemarie Meijer van het Instituut Biologie Leiden heeft nu ontdekt dat macrofagen in zebravissen beter in staat zijn tuberculose uit te schakelen als ze…
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Opruimactie tegen tuberculose en salmonella-infecties
Het eigen cellulaire recyclesysteem van zebravissen kan schadelijke bacteriën opeten en zo weerstand bieden tegen infecties als tuberculose en salmonellose. Dat schrijven Leidse biologen van de groep van Annemarie Meijer. Het stimuleren van deze vorm van afweer kan gebruikt worden in nieuwe behandelmethoden…
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Modeling Vascular Diseases Using Human Induced Pluripotent Stem Cells
Promotie
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Witte bloedcellen in transparante embryo’s
Leidse moleculair-celbiologen in de onderzoeksgroep van Annemarie Meijer hebben nieuwe genen ontdekt die specifiek tot expressie komen tijdens de vroege ontwikkeling van macrofagen in de zebravis, waaronder een signaaleiwit dat essentieel is voor de migratie van macrofagen tijdens de immuunreactie op…