36 zoekresultaten voor “macrophage differentiation” in de Publieke website
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Macrophage activation and cholesterol in atherosclerosis development
Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…
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Macrophage activation and cholesterol in atherosclerosis development
Promotores:Th.J.C. van Berkel, M. van Eck
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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PhD candidate in iPSCs pluripotency, differentiation potential and safety assessments
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Selective autophagy in host defense against mycobacterial infection
The effective treatment of tuberculosis (TB) remains a major challenge to global health.
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Key innate immune components controlling intracellular infection
Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Metabolic regulation of differentiation and maturation
Promotie
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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The role of the interleukin 12 family in atherosclerosis
Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager
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Chemokine signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Bone marrow transplantation in mice as a tool to study M2 macrophage activation in atherogenesis
Promotie
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Investigations on the role of impaired lysosomes of macrophages in disease
Promotie
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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The shell evolution of the Hydrocenidae of Malaysian Borneo
The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.
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Dynamic hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.
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Activity-based protein profiling in drug discovery
In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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Organ-Specific Barcodes in Human Fetal Development and Stem Cell Differentiation: The Pancreas in the Spotlight
Promotie
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PhD candidates in the field of supramolecular biomaterials
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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PhD candidate in the field of supramolecular biomaterials (1.0 fte)
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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PhD Positions Mainz
Within the Research Training Group 2304 “Byzantium and the Euro-Mediterranean Cultures of War. Exchange, Differentiation and Reception”, which is financed by the DFG (German Research Foundation), there are at the Johannes Gutenberg University of Mainz 2 positions for doctoral research associates (pay…
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Metagenomics for community ecology; a next generation of eDNA monitoring tool for biomass studies in freshwater environments
How can we quantify the density of species within a community through environmental DNA concentrations?
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PhD Positions Mainz
Within the Research Training Group 2304 “Byzantium and the Euro-Mediterranean Cultures of War. Exchange, Differentiation and Reception”, which is financed by the DFG (German Research Foundation), there are at the Johannes Gutenberg University of Mainz 6 positions for doctoral research associates (pay…
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This Week’s Discoveries | 15 November 2016
Lezing
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Verstoorde beweging maakt macrofagen dodelijker voor tuberculosebacteriën
Macrofagen – de frontlinie van ons afweersysteem – beschermen ons tegen infecties. Maar bij de tuberculosebacterie gaat dat vaak mis. De groep van Annemarie Meijer van het Instituut Biologie Leiden heeft nu ontdekt dat macrofagen in zebravissen beter in staat zijn tuberculose uit te schakelen als ze…
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Opruimactie tegen tuberculose en salmonella-infecties
Het eigen cellulaire recyclesysteem van zebravissen kan schadelijke bacteriën opeten en zo weerstand bieden tegen infecties als tuberculose en salmonellose. Dat schrijven Leidse biologen van de groep van Annemarie Meijer. Het stimuleren van deze vorm van afweer kan gebruikt worden in nieuwe behandelmethoden…
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Fluorescent Chemical Probes for Clinical Imaging Applications
Lezing
- This Week's Discoveries | 5 June 2018
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Making drugs from stem cells
Lezing, This Week's Discoveries
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ENW-Groot-subsidies voor Leidse bètawetenschappers
Leidse wetenschappers zijn hoofdaanvrager van vijf projecten die door NWO zijn gehonoreerd met een ENW-Groot-subsidie tot 3 miljoen euro in het domein Exacte en Natuurwetenschappen. Daarnaast zijn Leidenaren betrokken bij diverse andere gehonoreerde projecten.
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Effects of Prescriptivism in Language History
Congres/symposium