The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Promotor: Prof.dr. T. Hankemeier

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

My work focuses on a class of astronomical objects called protoplanetary disks.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Promotor: Prof.dr. E.F. van Dishoeck

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Promotor: A.P. IJzerman

Promotor: A.P. IJzerman

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

This thesis investigates the structural evolution and assembly of galaxies since the first few billions years after the big bang.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

Promotie

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotor: Prof.dr. E.F. van Dishoeck, Prof.dr. F.F.S. van der Tak (RUG)

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This thesis explores interfacial conductance and electric field-effects in LaAlO3/SrTiO3 heterostructures.

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Promotor: Prof.dr. G.P. van Wezel

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Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Promotie

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Alumna Simay Çetin heeft de Speckmann prijs gewonnen voor haar masterscriptie 'Interpreting Culture through Embodied Practice: An anthropological study of sexuality between Dutch Women with Turkish Migrant backgrounds'. Nova Folkersma, Marta Mas Castella, Iris Molenaar and Emma van der Plas kregen de…

How do nanoparticles bioaccumulate and biodistribute in organisms?

When observing star-forming galaxies, we are not only seeing stellar light, but we also see how this interacts with galactic gas and dust. This thesis contains studies of the stellar, nebular and dust properties of low mass star-forming galaxies.