The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

Promotor: J. A. Bouwstra

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Al sinds 1919 strijdt de International Labour Organization (ILO) voor de rechten van werkenden wereldwijd. De Universiteit Leiden is op 7 februari gastvrouw van het symposium waarmee de ILO haar 100-jarig bestaan viert. De Leidse emeritus hoogleraar Internationaal Arbeidsrecht Paul van der Heijden was…

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

De postdoc krijgt de onderscheiding voor haar proefschrift over de rol van Europese Unie-lidstaten bij het voorkomen van mensenrechtenschendingen door bedrijven.

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Het is onderzoekers voor het eerst gelukt grafeen op een stabiele laag vetten, ofwel lipiden, te plaatsen. Omringd door een beschermende laag van lipiden zou grafeen in het lichaam als een veelzijdige sensor kunnen dienen. De resultaten zijn de eerste stap naar zo’n omhulsel en zijn op 28 september…

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Promotor: A. Kros

Heart failure is a major health care problem with high mortality.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Promotor: A. Kros

Farmacoloog Walter Boiten ontwikkelde een nieuwe methode om de hoeveelheid vetten in iemands huid te kunnen bepalen. Met de methode testte hij de effecten van een nieuwe crème die hij ontwikkelde voor eczeempatiënten. De eerste resultaten zijn veelbelovend. Boiten promoveert op 15 januari.

Promotor: Prof.dr. G.P. van Wezel

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The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Lezing, Studium Generale

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

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Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

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Lezing

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

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Door het volgen van een master vergroot je je kansen op de arbeidsmarkt om een baan op niveau te vinden. Na de driejarige bachelor kun je direct doorstromen naar een één- of tweejarige master bij de Universiteit Leiden of een andere instelling.

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