39 zoekresultaten voor “kinetics” in de Publieke website
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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T-CYCLE EPR: Development at 275 GHz for the study of reaction kinetics & intermediates
A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.
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Unraveling the surface formation of regular and deuterated water in space: a combined laboratory and computational study
Promotor: Prof.dr. H.V.J. Linnartz
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Targeting the adenosinergic system
Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).
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Unraveling the mechanism of multicopper oxidases: from ensemble to single molecule
Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma
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Fluorescence Correlation Spectroscopy on Electron Transfer Reaction: Probing Inter- and Intramolecular Redox Processes
Promotores: G.W. Canters, T.J. Aartsma
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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Models of Nonlinear and Stochastic Astrochemical Kinetics
Promotie
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Electrochemical and surface studies of the effect of naphthalene-based additives on tin electrodeposition
Tin electrodeposition applications have rapidly evolved in the past 25 years.
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The role of water in hydrogen electrocatalysis
Promotor: M.T.M. Koper, Co-promotor: L. Juurlink
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Fermions and Bosons: Excitons in strongly correlated materials
Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp
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Postdoctoral researcher in structural biology of glycan-modifying enzymes
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
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Winds in the AGN environment: new perspectives from high-resolution X-ray spectroscopy
Promotor: J.S. Kaastra Co-promotor: E. Constantini
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Orion's Dragon and Other Stories
Stellar feedback is a crucial ingredient in the evolution of galaxies.
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FRESH Lezing: Computational Studies of Reactivity and Kinetics in Homogeneous Catalysis: Challenges and Perspectives
Lezing
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T-CYCLE EPR: Development at 275 GHz for the study of reaction kinetics & intermediates
Promotie
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
Promotie
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Dynamic hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Effect of Nanoparticles on Microbial Catabolism and Community Structure using Biolog techniques
1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Promotie
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PhD student, to identify and characterize inhibitors of carbohydrate modifying enzymes to generate a new type of anti-viral molecule
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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PhD candidate || Structure and dynamics in enzyme catalysis (1.0 fte)
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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PhD candidate || Identification and characterization of inhibitors of carbohydrate modifying enzymes to generate a new type of anti-bacterial
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Universiteit Leiden en Bayer leiden internationale samenwerking voor ontwikkeling nieuwe medicijnen
De Universiteit Leiden start samen met Bayer HealthCare een internationaal consortium ‘Kinetics for Drug Discovery’ (K4DD) dat onderzoek gaat doen naar optimaliseren van de ontwikkeling van nieuwe geneesmiddelen.
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Nieuw inzicht brengt duurzame waterstof dichterbij
Chemici Marc Koper en Ian McCrum hebben ontdekt dat de mate waarin een metaal bindt aan het zuurstofatoom van water beslissend is voor hoe goed de chemische omzetting van water tot waterstof verloopt. Dit inzicht helpt om betere katalysatoren te ontwikkelen voor de productie van duurzame waterstof,…
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Book presentation
Festival
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Laura Heitman benoemd tot Hoogleraar Moleculaire farmacologie
Per 1 november is Laura Heitman benoemd tot hoogleraar Moleculaire farmacologie bij het Leiden Academic Centre for Drug Research (LACDR). Heitman draagt bij aan de ontdekking van nieuwe geneesmiddelen door onderzoek naar de interactie tussen medicijnen en hun aangrijppunt in het lichaam. ’Mijn uiteindelijke…
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CANCELED: Joan van der Waals colloquium
Lezing
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Kunstmatig virus voor nieuwe medicijnen in gentherapie
Onderzoekers uit Leiden, Eindhoven en Nijmegen zijn er onder leiding van de Universiteit Wageningen in geslaagd om een kunstmatig virus te ontwikkelen. Dit kan gebruikt worden om in de toekomst nieuwe generaties medicijnen langs natuurlijke weg ‘in te pakken’ en af te leveren in zieke cellen. De ontdekking…
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This Week's Discoveries | 22 oktober 2019
Lezing
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Joan van der Waals colloquium - online
Lezing
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Ada Lovelace Distinguished Lecture Series
Lezing