In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

This thesis explores interfacial conductance and electric field-effects in LaAlO3/SrTiO3 heterostructures.

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).

Promotie

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

Promotor: J. Zaanen

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Ionische vloeistoffen zijn belangrijk binnen de wetenschap omdat ze veel lading kunnen aanbrengen over een oppervlak. Leidse fysici hebben nu ontdekt dat het ladingsproces binnen een ionische vloeistof puur afhankelijk is van tegengestelde ladingen die elkaar aantrekken. Chemische reacties zijn soms…

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Promotie

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotor: Prof.dr. M.L. van Hecke

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Promotor: M.A.G.J. Orrit

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

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In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn

Promotie

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

Lezing

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Promotor: Prof.dr. G.P. van Wezel

Met de NMR faciliteit doen we onderzoek naar de synthese van paramagnetische moleculen om kennis te vergaren over de structuur en dynamiek van eiwitten. Deze kennis kan dienen als basis voor een medicijn dat zich hecht aan een eiwit of voor de ontwikkeling van vaccins. Medicijnontwikkeling is één van…

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Promotor: G.P. van Wezel

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

Geometric phases lead to a nontrivial interference result when an electron's different quantum mechanical paths choices encircle a magnetic coil in an Aharonov-Bohm experiment.

Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

Promotie