Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Promotor: W.Th.F. den Hollander

This thesis discusses the discovery potential of Intensity Frontier experiments.

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

In this thesis, classes of strongly interacting quantum field theories, have been studied.

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

Promotores: F.H.J. Redig, W.T.F. den Hollander

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Het doel van het onderzoeksprogramma Systems Pharmacology ligt in de ontwikkeling van strategieën voor gepersonaliseerde geneesmiddelen en de ontwikkeling van nieuwe systeemgebaseerde benaderingen in de translationele en klinische farmacologie.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Het onderzoek van dit programma is gecentreerd rond dynamische systemen, functionele analyse en hun interactie.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Promotor: Prof.dr. H.J.A. Rottgering

Promotor: A. Kros

Deze opleiding is gericht op de ontwikkeling van computermodellen die de werking van medicijnen voorspellen, het individualiseren van bestaande behandeltherapieën en het ontwikkelen van innovatieve, analytische tools voor het personaliseren van de gezondheidszorg.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: Prof.dr. M.L. van Hecke

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Promotor: Prof.dr. S.F. Portegies Zwart

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Promotor: S.M. Verduyn Lunel

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

O-Nitrobenzyl groepen worden veel gebruikt als moleculaire beschermgroepen die je met licht kunt verwijderen.

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.