101 zoekresultaten voor “infection” in de Publieke website
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Key innate immune components controlling intracellular infection
Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer
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Selective autophagy in host defense against mycobacterial infection
The effective treatment of tuberculosis (TB) remains a major challenge to global health.
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Prosthetic Joint Infection, new diagnostic and treatment strategies
Promotie
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Computational modeling of mycobacterium infection and innate immune reponse in zebrafish
Promotor: Prof.dr. J.N. Kok
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extraembryonic serosa protects the insect egg against desiccation and infection
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Chemokine signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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modular goldnanoparticles for glycan-based immune-interventions of worm infections
Chiodo
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Researcher: Rapid MS-detection and characterization of variants of viral infections (1.0 fte)
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Bart Roep
Faculteit Geneeskunde
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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Cornelis Hokke
Faculteit Geneeskunde
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
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Cornelis van Kooten
Faculteit Geneeskunde
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Frank Baas
Faculteit Geneeskunde
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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Noortje Dannenberg
Wiskunde en Natuurwetenschappen
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Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
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Systems vaccinology: molecular signatures of immunity to Bordetella pertussis
Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz
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Viral infections in young infants
Promotie
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Diagnosis of tuberculosis infection before immunosuppression
Promotie
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
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Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Antibody Glycomics Signatures of SARS-CoV-2 Infection and Vaccination
Promotie
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Monitoring the immune responses to vaccination and infection
Promotie
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Strategies in prevention and treatment of prosthetic joint infections
Promotie
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Selective autophagy in host defense against mycobacterial infection
Promotie
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Anti-glycan antibody responses during infection with Schistosoma
Promotie
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Optimizing triage and treatment strategies in urinary tract infection
Promotie
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BK polyomavirus infection after kidney transplantation: risk and prevention
Promotie
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Host-Directed Therapy for Intracellular Bacterial Infections
Promotie
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Cytokine-mediated regulation of immunity during persistent viral infection
Promotie
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Functions of leptin in tuberculosis and diabetes: multi-omics studies across species
In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.
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The Function of Toll-like receptor 2 in Infection and Inflammation
Promotie
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Severe acute respiratory infections, the missing link in the surveillance pyramid
Promotie
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Controlled human infection models as a tool for malaria and schistosomiasis vaccine research
Promotie
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Epidemiology of Clostridium difficile infections in the Netherlands and Europe: implications for surveillance and control
Promotie
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Pathogenesis of congenital cytomegalovirus infection: finding prognostic markers and correlates of protection
Promotie
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New strategies for the prevention and treatment of burn wound infections
Promotie
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Plasmodium falciparum sporozoites in the controlled human malaria infection model
Promotie
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Chemokine signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
Promotie
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Synthesis of oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot