1,097 zoekresultaten voor “human skin equivalent” in de Publieke website
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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medium based approach to optimize the stratum corneum barrier of human skin equivalents
uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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Human Evolution
This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…
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Effects of human pressures on aquatic invertebrate
What are interactive effects of human pressures on aquatic communities?
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Humans of Psychology
Humans of Psychology plaatst studenten en medewerkers van het Instituut Psychologie in de spotlight. Of het nu gaat om inspirerend onderwijs, bijzonder onderzoek, een publieksbijeenkomst, open science of een bestseller. Neem een kijkje achter de schermen.
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Frontex and Human Rights
Melanie Fink, Postdoctoraal Onderzoeker bij het Europa Instituut van de Universiteit Leiden, heeft haar boek Frontex and Human Rights, Responsibility in 'Multi-Actor Situations' under the ECHR and EU Public Liability Law gepubliceerd. Dit boek is gebaseerd op haar proefschrift, dat zij in december 2017…
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Human iPSC Hotel
Het LUMC iPSC Hotel biedt de generatie van research grade humane geïnduceerde pluripotente stamcellen (iPSC's) uit verschillende weefselbronnen met behulp van de modernste herprogrammeringstechnieken.
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Frontex and Human Rights Responsibility
Woensdag 13 december verdedigde Melanie Fink haar proefschrift ‘Frontex and Human Rights: Responsibility in “Multi-Actor Situations” under the ECHR and EU Public Liability Law’.
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Can tigers survive in human-dominated landscapes?
S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.
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Human Rights Elephants in an Era of Globalisation: Commodification, Crimmigration, and Human Rights in Confinement
Op 21 januari 2020 verdedigde Patrick van Berlo zijn proefschrift 'Human Rights Elephants in an Era of Globalisation: Commodification, Crimmigration, and Human Rights in Confinement'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.P. van der Leun en prof.mr.dr. M.A.H. van der Woude.
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Applied Neuroscience in Human Development (MSc)
Voor wie geïnteresseerd is in de relatie tussen neuro-cognitieve en biologische factoren enerzijds en leren, gedrag en emoties anderzijds.
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Digital Media in Human Development (MSc)
De masterspecialisatie Digital Media in Human Development gaat over kansen en uitdagingen van digitale media in opvoeding en onderwijs.
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The Encyclopedia of Global Human Migration
The Encyclopedia of Global Human Migration biedt een complete verkenning van de prominente thema's, gebeurtenissen en theoretische onderbouwingen van de verplaatsingen van menselijke bevolkingsgroepen van de prehistorie tot heden.
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Human-lion conflict around nairobi national park
Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.
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Using Agent-Level Factors to Explain Variation in Human Rights Promotion Strategies
In dit artikel stelt Tom Buitelaar een systematisch kader voor om het effect van individuele kenmerken van vredeshandhavers op het gedrag van grondpersoneel bij VN-vredesoperaties te analyseren.
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Humans of Humanities
In de serie Humans of Humanities, lichten wij iedere twee weken een van onze wetenschappers, medewerkers of studenten uit.
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Human-wildlife Interactions in the Western Terai of Nepal
Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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Voorlichtingsactiviteiten
Kom naar onze online en oncampus events om ons beter te leren kennen!
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The future of AI is human
Van zelfrijdende auto’s tot innovatieve medicijnontwikkeling, kunstmatige intelligentie (AI) gaat ons leven op uiteenlopende manieren fundamenteel veranderen. Onze computerwetenschappers bestuderen de technologie op een diep en fundamenteel niveau. Maar we zoeken ook naar medische toepassingen en antwoorden…
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Ecology and conservation of spotted hyena in human dominated landscapes in northern Ethiopia
Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen)
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.
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European and International Human Rights Law (Advanced LL.M.)
Leiden University’s Master of Law in European and International Human Rights Law (L.L.M.) looks at the various protection mechanisms applied to human rights across different political, social and cultural settings.
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof
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Hard power and the European Convention on Human Rights
Op 18 juni 2019 verdedigde Peter Kempees zijn proefschrift 'Hard power and the European Convention on Human Rights'. Het promotieonderzoek is begeleid door promotoren prof. dr. R.A. Lawson en prof. dr. H. Duffy.
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Comparative ecology and genetics of sympatric wild cats in relation to human wildlife conflict in Bardia National Park, Nepal
What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…
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Catecholamine function, brain state dynamics, and human cognition
Het onderzoek in dit proefschrift kijkt naar de rol van het locus ceuruleus - noradrenalinesysteem in verscheidene aspecten van menselijke cognitie, en de modulatie van de staat van het brein.
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Proving discriminatory violence at the European Court of Human Rights
Op dinsdag 23 mei 2017 verdedigde Jasmina Mackic haar proefschrift ‘Proving discriminatory violence at the European Court of Human Rights’. De promotor is vice-decaan en hoogleraar internationaal publiekrecht Larissa van den Herik. Hieronder volgt een korte samenvatting van haar proefschrift.
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Human-lion conflict around Nairobi National Park: Lion Population Structure, Diet, and Movement in a Semi-Fenced Park.
What is the population size and social structure in time and space? What is the lion diet and food preference in time and space? What is the home range (MCP and Kernel) and movement in time and space? What are human – lion conflict and responses of lions to traditional herding in time and space? What…
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pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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publiceert boek Core Socio-Economic Rights and the European Court of Human Rights
Bij Cambridge University Press (CUP) verscheen onlangs van Ingrid Leijten het boek Core Socio-Economic Rights and the European Court of Human Rights. Het boek maakt onderdeel uit van de serie Cambridge Studies in European Law and Policy en heeft als onderwerp de bescherming van sociaaleconomische rechten…
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Ecology of the Ethiopian wolf in a changing landscape: Human carnivore interactions in Afroalpine ecosystems of Ethiopia
Do Ethiopian wolves change their diet and foraging strategy in the landscape under different land uses? How land use affect Afro-alpine rodent Communities? How important are Afro-alpine natural resources utilisation for local livelihoods? What is the human perception of conflict in the Afro-alpine a…
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Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
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Transfer of "goods" from plants to humans: Fundamental and applied biochemical investigations on retaining glycosidases
The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.
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onderzoek aan Siracusa International Institute for Criminal Justice and Human Rights
Op 3 en 4 maart vond de 2e PhD Seminar over internationaal strafrecht, internationale mensenrechten en internationaal humanitair recht plaats aan het Siracusa International Institute for Criminal Justice and Human Rights op Sicilië. Ida Asscher en Anna Smulders, beiden promovenda aan het Grotius Centre…
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Child Marriage as a Choice: Rethinking agency in international human rights
Op 18 maart 2020 verdedigde Hoko Horii haar proefschrift 'Child Marriage as a Choice: Rethinking agency in international human rights'. Het promotieonderzoek is begeleid door promotoren prof.dr. A.W. Bedner en prof.dr. G.A. van Klinken (UvA).
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Impact of land use changes on the human-elephant conflict
Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh
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publicatie: Proving Discriminatory Violence at the European Court of Human Rights
Jasmina Mačkić, Universitair Docent Mensenrechten bij het Europa Instituut, heeft haar boek, Proving Discriminatory Violence at the European Court of Human Rights, gepubliceerd. Deze publicatie is gebaseerd op haar proefschrift die Mačkić in mei 2017 heeft verdedigd. Het onderzoek is mogelijk gemaakt…
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach
Op 7 mei 2020 verdedigde Jolanda van der Vliet proefschrift 'The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.J. Schrijver en prof.dr.ir. J.J.C. Voorhoeve.
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The Interactions of Human Mobility and Farming Systems and Impacts on Biodiversity and Soil Quality in the Western Highlands of Cameroon
Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh