Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Promotor: M.A.G.J. Orrit

This thesis focuses on the study of transient and variable radio sources in the universe.

Wiskunde en Natuurwetenschappen

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotor: Prof.dr. C.U. Keller

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Promotie

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Promotie

Sterrewacht Leiden is het sterrenkundig instituut van de Faculteit der Wiskunde en Natuurwetenschappen van de Universiteit Leiden.

Hoogleraar Fons Verbeek, verbonden aan de informatica- en biologie-instituten van de Universiteit Leiden, heeft de fascinatie om alles wat we niet direct kunnen zien, toch in beeld te brengen. Op SleutelstadFM vertelt hij dat door het omrekenen van 2 dimensionale (2D) beelden naar 3 dimensionale (3D)…

Huub de Groot

Hoe breng je larven van de zebravis microscopisch in beeld? De nieuwe gratis online cursus ‘Imaging the Vertebrate embryo’ leert je er alles over. Leidse promovendi Salomé Muñoz Sánchez en Radoslaw Gora werkten mee aan de cursus.

Promotor: B. van de Water

The LIACS Media Lab has received a research grant from the worldwide leading graphics hardware company NVIDIA. The grant exists of newly developed hardware utilizing thousands of processors. LIACS researchers will use it to investigate deep learning in understanding imagery from sources such as MRI…

Promotie

Oratie

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Promotie

Promotor: M. Franx, Co-Promotor: I.F. Labbé

Promotie

Lezing

Promotie

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Promotie

Lezing, LIBC Sylvius lecture

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

Promotie