Promotor: M.A.G.J. Orrit

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

Promotor: M.A.G.J. Orrit

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Fate and toxicity of copper nanoparticles was related to the water chemistry of the environment and pristine size.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Promotor: T.J. Aartsma, Co-promotor: R.N. Frese

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

This thesis describes a study from both a theoreticaL and an experimental point of view.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Promotor: Prof.dr. J.W.M. Frenken

Promotor: A. Kros

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Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. It is the main cause of birch pollen allergy in humans.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

Promotie

Lezing

Promotie

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Individuele moleculen zijn extreem moeilijk te zien via hun zwakke fluorescentie. Piepkleine gouden nanostaafjes fungeren als nieuwe antennes om hun signaal 500 maal te versterken. Publicatie op 24 februari in Angewandte Chemie.

Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?

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Emeritus hoogleraar Rob Verpoorte kreeg de hoogste wetenschappelijke onderscheiding van de Society for Medicinal Plant and Natural Product Research uitgereikt.

Promotor: W. Jiskoot, Co-promotor: A. Kros

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Promotie

Hoe kan de methode om de gecombineerde effecten van metaal-gebaseerde chemische stoffetn te bepalen worden verbeterd?

Ilya Kokorin, Meijers PhD-kandidaat bij de afdeling Financieel recht, heeft de Gold Medal in de prestigieuze competitie van het International Insolvency Institute (III) gewonnen, de 2020 Prize in International Insolvency Studies. Deze prijs wordt toegekend aan een origineel juridisch onderzoek, commentaar…

Promotores: W. Jiskoot, F. Ossendorp

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Promotores: Wim Jiskoot; Ferry Ossendorp

Promotor: J.W.M. Frenken Co-Promotores: I.M.N. Groot; L.B.F. Juurlink

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Wat zijn de risico's van nanodeeltjes?

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