The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Promotor: A.P. IJzerman

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Promotor: A.P. IJzerman

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Promotor: A.P. IJzerman

Promotor: Prof.dr. M. Ubbink

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

During the course of drug discovery translational steps are made.

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Promotie

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Informatie over de de G. Rosenberg Research Award van het Leiden Institute of Advanced Computer Science (LIACS) is beschikbaar in het Engels.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Promotie

Afscheidscollege

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Promotie

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

HDL staat bekend als het ‘goede cholesterol’: het verlaagt de kans op hart- en vaatziekten. Sommige families hebben van nature veel HDL in het bloed. Onderzoek naar hun erfelijk materiaal kan bijdragen aan de ontwikkeling van nieuwe medicijnen die HDL verhogen.

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Promotie

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Medicijnen werken niet volgens het ‘one size fits all’-principe, omdat genetische verschillen hun effectiviteit beïnvloeden. Dat blijkt uit innovatief onderzoek van promovendus Julia Hillger. Zij promoveert donderdag 7 december op haar proefschrift Take it Personal.

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Met het onderzoek ‘Baby’s eerste hapjes’ willen wij meer te weten komen over de overgang naar vast voedsel bij baby’s. Zo zijn we benieuwd hoe de overgang naar vast voedsel bij kinderen verloopt, hoe het eetpatroon van kinderen zich na de overgang verder ontwikkelt en hoe ouders deze overgang en het…

De Academy of Creative and Performing Arts biedt in samenwerking met een aantal instellingen voor hoger onderwijs in de kunsten, twee PhD-programma’s aan: in de muziek (docARTES) en de beeldende kunst en vormgeving (PhDArts). Deze programma's zijn beide internationale doctoraatsprogramma's voor praktijkgericht…

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs