How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Promotor: E.F. Smets, Co-promotor: J. Geml

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Promotor: E.F. Smets Co-promotor: J. Geml

What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

Promotor: Prof.dr. G.P. van Wezel

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Prof.dr. J. Memelink

Lees hier alles over de verschillende projecten van de Young Academy Leiden.

De afdeling Environmental Biology (CML-EB) houdt zich bezig met vraagstukken rondom biodiversiteit en natuurlijke hulpbronnen op het platteland in westerse en niet-westerse gebieden.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

In 2019 bestond de Universiteit Leiden 444 jaar. Deze bijzondere leeftijd vroeg om een bijzondere viering, samen met de inwoners van Leiden en Den Haag. In, met en voor de stad.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotie

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotie

Promotie

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

De Young Academy Leiden (YAL) is een selecte groep jonge academici aan de Universiteit Leiden. De YAL, opgericht in begin 2019, dient als platform om enthousiaste en ambitieuze jonge academici (post-PhD), die aan het begin van hun carrière staan, bij elkaar te brengen. YAL-leden vertegenwoordigen…

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Promotores: G.W. Canters, T.J. Aartsma

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Hermen Overkleeft ontving samen met Bobby Florea een Zenith subsidie ​​van het Horizon-programma van het Nederland Genomics Initiative voor hun voorstel Quantative functional enzyme profiling: a versatile strategy to monitor disease progression and to validate new therapeutic strategies'.

Professor dr. C. van den Hondel is gisteren benoemd tot Officier in de Orde van Oranje-Nassau voor zijn grote rol in het Nederlandse Moleculair Genetisch onderzoek naar schimmels.

Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…

Tijdens het symposium van de sectie Organische Chemie op 10 april 2015 is de winnaar van de Backer-KNCVprijs bekend gemaakt. De prijs gaat dit jaar naar Lianne Willems.

De Leidse hoogleraren chemie Hermen Overkleeft en Hans Aerts hebben, samen met hun collega Huib Ovaa van het Nederlands Kankerinstituut, 2 miljoen euro gekregen van NWO voor biochemisch onderzoek. Het onderzoek kan leiden tot nieuwe behandelingsmethodes voor verschillende ziektes.

Op donderdag 18 februari heeft de webinar Jeugd, hersenwetenschap en recht plaatsgevonden.