813 zoekresultaten voor “functional molecules” in de Publieke website
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Charge transport properties of Ru-complex molecules: the influence of humidity
I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.
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Exploring charge transport properties and functionality of molecule-nanoparticle ensembles
Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen
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Rationally designed peptide based functional biomaterials
Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
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Organische moleculen in de ruimte
Dishoeck
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Understanding functional dynamics and conformational stability of beta-glycosidases
Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.
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Sequencing biological molecules with graphene
Schneider
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Plasmonic enhancement of one-photon- and two-photon-excited single-molecule fluorescence by single gold nanorods
This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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Remote sensing-based assessment of functional diversity for polar ecosystems
1: What is the relative importance of alfa and beta biodiversity in polar ecosystems, and how does intraspecific variation influence this? 2: How can we use remote sensing to determine functional biodiversity (within communities) in polar ecosystems? 3: Temporal and spatial scales of functional biodiversity:…
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Electronic spectroscopy of molecules of astrophysical interest
This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).
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Ab initio molecular dynamics calculations on reactions of molecules with metal surfaces
Promotor: Prof.dr. G.J. Kroes
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
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Molecules during stellar formation and death
Promotor: Prof.dr. E. F. van Dishoeck
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Functional xylem anatomy: intra and interspecific variation in stems of herbaceous and woody species
My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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Small-molecule inhibitors of bacterial metallo-β-lactamases
The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).
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Functional analysis of Dof transcription factors controlling heading date and PPDK gene expression in rice
Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang
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The formation of complex organic molecules in dense clouds-Sweet results from laboratory
Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.
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Semi-empirical approach to the simulation of molecule-surface reaction dynamcis
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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NMR structural studies of protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Unraveling the mechanism of multicopper oxidases: from ensemble to single molecule
Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma
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Fungi of the greening Arctic: compositional and functional shifts in response to climatic changes
Promotor: E.F. Smets Co-promotor: J. Geml
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Beyond the Born-Oppenheimer Static Surface Model for Molecule- Surface Reactions
Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.
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Stable single molecules for quantum optics and all-optical switches
Promotor: Prof.dr. M.A.G.J. Orrit
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.
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The astrochemical factory: A solid base for interstellar reactions
In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.
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Biophysical characterization of membrane protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink
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PhD candidate in bio-synthetic chemistry of small-molecule drugs targeting viral RNAs
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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the structure and chemistry of planetary birthplaces with simple molecules
This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Van moleculen naar planeten: Verkennen van de chemische erfenis van zonnestelsels
Walsh
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Functional characterization and unraveling the Gene Regulatory Networks (GRNs) of HD-Zip transcription factor HB40 (and HB22) in Arabidopsis
In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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SDS-PAGE at the nanoscale: A nanorecorder for single molecule protein sequencing with graphene
Schneider
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From molecules to monitoring: Integrating genetic tools into freshwater quality assessments
Promotie
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Oratie: Het molecuul, de cellen en het weefsel: de wiskunde van groei en vorm in tijden van Big Data
Pas als we stap voor stap een plant of dier kunnen ‘bouwen’, begrijpen we hoe het organisme werkt. Zo kunnen we volgen en invoelen hoe eiwitten en DNA zich organiseren tot cellen en hoe cellen zich logischerwijs wel moeten organiseren tot weefsels, organen en hele dieren. Pas dan begrijpen we echt hoe…
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Linking simple molecules to grain evolution across planet-forming disks
Planets are formed in disks of gas and dust around young stars.
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Mosselen organiseren zich als moleculen in materiaal
Mosselen in mosselbedden vormen een patroon dat lijkt op de organisatie van moleculen en atomen in materialen als brons, staal of rubber. Dit gedrag kan dan ook worden beschreven met hetzelfde wiskundige model.
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Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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Synthetische moleculen leren om te communiceren
Pas sinds maart dit jaar werkt Sander Wezenberg in Leiden, maar hij heeft nu al een Vidi-beurs van NWO binnen weten te halen. Geïnspireerd door de natuur wil Wezenberg synthetische moleculen tot leven wekken en ze leren communiceren. Maar wie is Wezenberg precies en wat drijft hem?
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Ziektes detecteren met moleculen in het lichaam
Is het mogelijk om ziektes te diagnosticeren met behulp van moleculaire schakelaars? Over die vraag buigt het nieuwe internationale consortium LogicLab zich. Vanuit Leiden zijn scheikundige Sylvestre Bonnet en farmacoloog Thomas Hankemeier betrokken. Het project loopt voor vier jaar en krijgt ruim 3,5…
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Snelheidscontrole voor moleculen
Moleculen detecteren met temperatuur in plaats van chemische reacties: dat is wat wetenschappers van het Leids Instituut voor Onderzoek in de Natuurkunde willen doen. Ze ontwikkelen een sensor die speciale nanodeeltjes gebruikt om moleculen in de gaten te houden. Op deze manier kunnen ze bijvoorbeeld…
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Novel Protecting Group Strategies in the Synthesis of Oligosaccharides
The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.
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Kaixuan PanWiskunde en Natuurwetenschappen
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Moleculen tellen in levende cellen
Biofysicus Rolf Harkes heeft een microscoop ontwikkeld die individuele moleculen kan lokaliseren in levende cellen. Dit verbetert de traceertechnieken voor ziektes als kanker en Parkinson op cellulair niveau. Promotie op 13 januari 2016
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Moleculen bouwen met duurzame elektriciteit
Om in 2050 de CO2-uitstoot naar nul te brengen, is het NWO-programma E2CB gestart. Het doel: alle grondstoffen voor de chemische industrie uit duurzame bronnen produceren. Hoogleraar Elektrochemie Marc Koper is vanuit Leiden betrokken.
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Nieuw molecuul gevonden in planetaire nevel
Een team van astronomen, onder leiding van de Leidse astronoom Isabel Aleman, heeft voor het eerst een molecuul gevonden dat nodig is voor het ontstaan van water in planetaire nevels. Het onderzoek is op 17 juni gepubliceerd in het tijdschrift Astronomy & Astrophysics.