Promotor: W. Jiskoot, Co-promotor: A. Hawe

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotores: W. Jiskoot, F. Ossendorp

Promotores: Wim Jiskoot; Ferry Ossendorp

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotie

Promotie

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Promotie

Promotor: W. Jiskoot, Co-promotor: A. Kros

In this work, we attempt to answer the question:

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

CONSENT (Consumer sentiment regarding privacy on user generated content services in the digital economy) is a research project funded by the European Union under the 7th Framework Programme. The question central to this research is whether recent changes to consumer and commercial practices developed…

Hoe gevaarlijk zijn micro- en nanoplastics? Hebben ze invloed op het milieu? Zijn ze schadelijk voor ons lichaam? Deze vragen kunnen we dankzij Fazel Abdolahpur Monikh eindelijk gaan beantwoorden. Samen met zijn collega’s ontwikkelde hij een methode om plasticdeeltjes van nanoformaat te detecteren en…

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

In mei 2017 zal het driejaarlijkse FIP Pharmaceutical Sciences World Congress (PSWC) worden gehouden in Stockholm. We hadden een interview met de congresvoorzitter: Professor dr. Meindert Danhof van het LACDR, Universiteit Leiden.

Lezing

Lezing

Promotie

Promotie

Round Table

Congres/symposium