Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Promotor: Prof.dr. J. Kuiper

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Promotor: J.N. Kok, Co-promotor: C.M. Soares, A.J. Knobbe

Supervisor: P.J.J. Hooykaas

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Promotor: A.P. IJzerman

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Consequences for sediment stability and seston trapping

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Promotor: E.F. Smets, Co-promotor: T.R. van Andel

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

De Gouy-Chapman-theorie beschrijft wat er gebeurt in de buurt van een elektrode in een zoutoplossing, maar doet dat niet correct. Onderzoeker Kasinath Ojha, universitair docent Katharina Doblhoff-Dier en hoogleraar Marc Koper presenteren een nieuwe versie. ‘De volgende generatie studieboeken over elektrochemie…

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Het Mathematisch Instituut is een van de acht instituten van de Faculteit der Wiskunde en Natuurwetenschappen. Het instituut opereert als een eenheid gedefinieerd door de activiteiten van de medewerkers

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Een internationaal team van sterrenkundigen, onder wie Jelle Kaastra, heeft een nieuwe verklaring gevonden voor röntgenstraling in clusters van sterrenstelsels. Deze röntgenstralen kunnen ontstaan als koud waterstofgas botst op hete zwavel-ionen en zo elektrische lading overdraagt. Eerder werden de…

Nog nooit was een kristalstructuur van een menselijk eiwitmolecuul in een celwand zo kristalhelder. De Leidse onderzoekers Ad IJzerman en Laura Heitman maakten samen met Amerikaanse collega’s de meest gedetailleerde kristalstructuur ooit van een doeleiwit voor geneesmiddelen. De onderzoekers publiceerden…

What are the life-cycle environmental impacts and risks to human health and ecosystems of a III-V/Si PV system? How can these be expected to change when the system is deployed at industrial scale? What are the most favourable recycling scenarios?

Accumulation of metals in economy and environment and its associated risks, within the Netherlands and the EU.

What are trait-trait relationships in wetlands? To what extent the so-called leaf economics traits deviate from terrestrial ecosystems? How traits specific to wetland plant relate to plant strategies? What’s the relationship between wetland plant traits to the ecosystem functioning (e.g. productivity,…

The aim of our research program is to better understand the aetiology and course of mood, anxiety and trauma and stressor-related disorders and to test and improve treatments for these disorders.

What is the role of the rebound effect in achieving environmental savings from transport eco-innovation? Are traditional definitions of the rebound effect adequate in the context of transformative innovations and multidimensional environmental issues?

Wiskunde en Natuurwetenschappen, Leids Instituut voor Onderzoek in de Natuurkunde (LION)