Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

Promotor: A.P. IJzerman

Promotor: A.P. IJzerman

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Promotor: Prof.dr. E. Bouwman

Promovenda Gineke Wiggers heeft de 2e prijs gewonnen voor haar paper over User-Focused Ranking in Legal Information Retrieval in het PhD consortium van de 31e International Conference on Legal Knowledge and Information Systems (JURIX).

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

De jaarlijkse LION Image award gaat naar de foto van een 30 micrometer lang 3D-geprint bootje dat in oktober viraal ging, ingediend door Rachel Doherty van de groep van Daniela Kraft.

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Volgens astrochemici komt het Cyclopropenyl-ion molecuul veel voor in het heelal, maar er kon niet gericht naar worden gezocht met telescopen. Na een decennialange zoektocht is het lichtspectrum in het laboratorium gemeten. Het molecuul is een tussenproduct van chemische reacties die een rol spelen…

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

Promotie

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

Promotie

Promotor: J. Schaye

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Promotor: I. Snellen, Co-Promotor: M. Kenworthy

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

In this study the flows of PVC and its additives through the Swedish Society were followed from the cradle to the grave (from production to waste treatment).

D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…

In this thesis, classes of strongly interacting quantum field theories, have been studied.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Surface plasmons (SPs) are surface waves at the interface between a dielectric and a good metal, and are formed by the interaction between light and the free electrons at the metal-dielectric interface. They provide strong field confinement for optical fields, opening new possibilities for enhanced…