De Viral Vector Facility produceert partijen lentivirus en adenovirus voor preklinisch onderzoek binnen het LUMC. Daarnaast helpt het onderzoekers bij het produceren van eigen virussen.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Promotor: W. T. F. den Hollander, F. H. J. Redig

This thesis consists of three papers that are centered around the common theme of Hausdorff uo-Lebesgue topologies and convergence structures on vector lattices and on vector lattices and vector lattice algebras of order bounded operators.

Promotores: J.N. Kok, H.J. Hoogeboom

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

This thesis mainly extends the theory of positive operators on Riesz spaces to a setting of pre-Riesz spaces.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Moet je alles kunnen zeggen op Twitter en Facebook? Is Instagram moreel verplicht foto’s te verwijderen van aanslagen? Moeten we toestaan dat terroristische groepering nieuwe leden werven op het internet?

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

In dit onderzoek worden orde isomorfismen en orde antimorfisme bestudeerd in het algemene kader van partieel geordende vector ruimten.

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

Promotor: Prof.dr. T.H.W. Bäck

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Promotie

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

Kunst en vrije tijd, Kunst en vrije tijd

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…

Promotores:Th.J.C. van Berkel, M. van Eck

Promotor: J.M. Memelink

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

From the 1920s on, popular music in Southeast Asia was a mass-audience phenomenon that drew new connections between indigenous musical styles and contemporary genres from elsewhere to create new, hybrid forms. This book presents a cultural history of modern Southeast Asia from the vantage point of popular…

Op 1 juni 2022 verdedigde Tom Herrenberg het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. P.B. Cliteur en prof.dr. B.R. Rijpkema.

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotie

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

HEPGAME is a research project that combines the world’s fastest computer algebra system for High Energy Physics equations, FORM, with insights from artificial intelligence. The name combines High Energy Physics and Games.