The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Promotie

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Rechtsgeleerdheid, Instituut voor Privaatrecht

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Promotie

Promotor: Prof.dr. J. Kuiper

Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Op 22 januari 2020 verdedigt Annemarie Madani-Abbing haar proefschrift 'Art Therapy & Anxiety'.

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

Technologische ontwikkelingen gaan in een razend tempo, zo ook op het gebied van kunstmatige intelligentie. Voor minderheidsgroepen zoals de LHBT+ gemeenschap kan die ontwikkeling echter gevaarlijk zijn, schrijft onderzoeker Eduard Fosch Villaronga in een ingezonden brief in Nature Machine Intellige…

Stress komt veel voor in de huidige samenleving. Dit is zorgwekkend, aangezien onderzoek herhaaldelijk heeft aangetoond dat stress een negatieve invloed heeft op de lichamelijke gezondheid. Zo vergroot stress bijvoorbeeld de kans op hart- en vaatziekten.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Programma's die de symptomen van sociale angst bij kinderen willen verminderen, omvatten doorgaans meerdere onderdelen, zoals blootstelling en mentale herstructurering. Het is onbekend of afzonderlijke onderdelen positieve effecten opleveren bij kinderen of dat een combinatie van onderdelen nodig is…

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Lezing, Lecture is in English

Promotie

Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink

Promotie

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotor: Prof.dr. B. van de Water

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Promotie

Promotie

De GMP-faciliteit maaktde ontwikkeling en productie van Advanced Therapy Medicinal Products (ATMP's) en chemische (peptide) synthese mogelijk.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Bacteria have the ability to alter their morphology in order to adapt to changing environments.