Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

We consider the propagation of electrical signals through nerve fibres.

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

In this thesis three different topics in number theory are studied.

Op woensdag 5 juni gaf Kalin Anev Janse, Secretaris-Generaal en lid Raad van Bestuur van het European Stability Mechanism (ESM), een lezing getiteld 'Bridging decision-making: a new direction for Europe? Prioritising financial stability: the European Stability Mechanism and the Banking Union'.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

An algorithm is discussed to compute the exponential representation of principal units in a finite extension field F of the p-adic rationals.

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

In my research, we developed a method to distinguish knots. A knot is a mathematical depiction of the everyday knot that occurs in ropes and cords.

Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

In this thesis we study bistable reaction-diffusion equations on lattice domains.

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

Lezing

Promotor: W. Jiskoot, Co-promotor: H.A. Every

Lezing

Promotores: R. Tijdeman, K.J. Batenburg

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

Promotie

Promotor: Prof.dr. F. den Hollander, G.Maillard

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

Promotor: F. Arbab, R. De Nicola, Co-Promotor: M. Tribastone

The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

The focus of the dissertation

Promotor: A. Kros

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.