The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

Naar schatting bestaat de wereldbevolking over twintig jaar uit ongeveer 8,7 miljard mensen, terwijl dat aantal nu 7,3 miljard is. Deze groei, gecombineerd met de bijbehorende groei in consumptie en de verbeteringen in levensstandaarden, zal resulteren in een enorme groei in de vraag naar voedsel, verbruiksgoederen,…

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

Examining if large scale application of new energy pathways can be constrained by materials and emissions.

Governance and Global Affairs

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Hetterscheid

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Promotor: Roeland M.H. Merks

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

Existing work in probabilistic language modeling can be mostly divided into two categories: (i) Purely sequential, string-level approaches ensure fluency at the local level without notion of grammaticality and seek improvements in the use of massive training corpora. (ii) Fully structural, tree-based…

... which builds on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

In this thesis, classes of strongly interacting quantum field theories, have been studied.

Promotor: Prof.dr. E. Deprettere

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Peter Grunwald

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Promotor: B.van de Water, Co-promotor: L.S.Price

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Juurlink

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Promotor: Prof. dr. A.G.G.M. Tielens

Promotor: Prof.dr. J.N. Kok