This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

This thesis focuses on addressing four research problems in designing embedded streaming systems.

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Promotor: Prof.dr. E. Deprettere

The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

Wetenschappers bij de Leidse Sterrewacht onderzoeken de fundamenteel natuurkundige verschijnselen die voor structuur in het heelal zorgen. Deze processen brengen materie bijeen tot sterrenstelsels en gas bijeen tot sterren. Met behulp van krachtige telescopen en geavanceerde berekeningen en computersimulaties…

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.

Het doel van het onderzoeksprogramma Systems Pharmacology ligt in de ontwikkeling van strategieën voor gepersonaliseerde geneesmiddelen en de ontwikkeling van nieuwe systeemgebaseerde benaderingen in de translationele en klinische farmacologie.

Het Streaming the Past project, opgezet door archeologen en historici van de Universiteit Leiden, heeft recentelijk een NWA-beurs toegekend gekregen. Het Leidsch Dagblad en universitair weekblad Mare schreven een artikel over dit bijzondere project.

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Het onderzoek van dit programma is gecentreerd rond dynamische systemen, functionele analyse en hun interactie.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Een groep onderzoekers van de Faculteit Geesteswetenschappen en Archeologie, ondersteund door de communicatie-afdelingen van deze faculteiten en stichting VALUE, hebben een van deze eerste NWA-wetenschapscommunicatie en outreach beurzen gekregen voor hun plan om live-streams te produceren via online…

Deze opleiding is gericht op de ontwikkeling van computermodellen die de werking van medicijnen voorspellen, het individualiseren van bestaande behandeltherapieën en het ontwikkelen van innovatieve, analytische tools voor het personaliseren van de gezondheidszorg.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

What would be the environmental performance of the Carbon4PUR technology at industrial scale in the future?

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Promotor: Prof.dr. S.F. Portegies Zwart

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Promotor: S.M. Verduyn Lunel

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotor: K.H. Kuijken

O-Nitrobenzyl groepen worden veel gebruikt als moleculaire beschermgroepen die je met licht kunt verwijderen.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

What are the flows of C&DW (e.g. bricks, concrete, gypsum and wood) in the case study countries ? How to define the specification for each material to be quantified? What indicators should be used to identify the pattern of each C&DW management system? How to interpret the MFA results in relation…

Promotie

What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Promotores: W. Jiskoot, F. Ossendorp

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma