Wiskunde en Natuurwetenschappen

Het doel van deze faciliteit is om het biomedisch onderzoek te versnellen door toegang te bieden tot geavanceerde licht- en elektronenmicroscopie en door het delen van expertise over monstervoorbereiding, beeldvormingsmodaliteiten, gegevensopslag en beeldanalyse.

Electron microscopy has become an extremely important techniquein a wide variety of elds.

The dissertation describes TEM experiments on heterogeneous catalysts.

Wiskunde en Natuurwetenschappen

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

This thesis describes a study from both a theoreticaL and an experimental point of view.

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

De Microscopy Unit huisvest, onderhoudt en coördineert vrijwel alle microscopieapparatuur van het IBL. De beschikbare apparatuur varieert van conventionele licht- en fluorescentiemicroscopen tot confocale laser- en elektronenmicroscopen. Er is bovendien apparatuur beschikbaar voor histologie, met inbegrip…

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Promotor: T. Schmidt

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

Promotor: T.H. Oosterkamp

Onderzoeksgroepen in het Quantum Matter & Optics onderzoeksprogramma onderzoeken elektronische eigenschappen van interacties van materie en lichtmaterie, met de nadruk op quantuminformatie.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

Natuurkundige Daniël Geelen ontwikkelde tijdens zijn promotie een nieuwe microscoop die laag-energetische elektronen gebruikt. Zulke elektronen zijn minder schadelijk voor biologische en organische materialen. Geelen promoveert op 31 mei.

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

Promotie

Promotor: Prof.dr. J.W.M. Frenken

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Promotor: J. Zaanen, Co-Promotor: V. Juricic

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

Promotores: G.W. Canters, T.J. Aartsma

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Onderzoek in de Natuurkunde (LION)

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Een speciaal type microscoop jaagt momenteel een revolutie aan in de biologie: de cryo-elektronenmicroscoop. Twee van zulke giganten staan sinds 2011 op de Leidse Faculteit der Wiskunde en Natuurwetenschappen. Hoogleraar Ultrastructuurbiologie Ariane Briegel vertelt hierover in het NRC Handelsblad.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Promotor: B. van de Water

Promotor: B. van de Water

Promotie

Het logo van de Universiteit Leiden, met letters zo klein als een bacterie. Wetenschappers van het LUMC en het Instituut Biologie hebben het kleinste logo ooit van onze universiteit gemaakt. Een grapje met een serieuze ondertoon: met de nieuwe microscoop waarmee het logo is gemaakt, kunnen zij nog gedetailleerder…

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Promotor: H.J.M. de Groot