Electron microscopy has become an extremely important techniquein a wide variety of elds.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

This thesis describes a study from both a theoreticaL and an experimental point of view.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Het doel van deze faciliteit is om het biomedisch onderzoek te versnellen door toegang te bieden tot geavanceerde licht- en elektronenmicroscopie en door het delen van expertise over monstervoorbereiding, beeldvormingsmodaliteiten, gegevensopslag en beeldanalyse.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

The dissertation describes TEM experiments on heterogeneous catalysts.

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

Promotor: J. Zaanen, Co-Promotor: V. Juricic

Promotores: G.W. Canters, T.J. Aartsma

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Een bacterie supersnel bevriezen, om de structuur van buiten en binnen natuurgetrouw in beeld te brengen. Hoogleraar Ultrastructuurbiologie Ariane Briegel kwam speciaal hiervoor naar Leiden: de Universiteit Leiden is een van de weinige instituten wereldwijd waar de benodigde apparatuur beschikbaar is.…

Hoe detecteren bacteriën signalen uit hun omgeving en hoe passen ze zich daaraan aan? Die vraag intrigeert Ariane Briegel, hoogleraar Ultrastructuurbiologie. Met behulp van nieuwe technieken produceert ze driedimensionale beelden, die nieuwe informatie geven over het zintuiglijke systeem van bacteri…

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Promotie

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

Onderzoeksgroepen in het Quantum Matter & Optics onderzoeksprogramma onderzoeken elektronische eigenschappen van interacties van materie en lichtmaterie, met de nadruk op quantuminformatie.

Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.

Promotie

Natuurkundige Daniël Geelen ontwikkelde tijdens zijn promotie een nieuwe microscoop die laag-energetische elektronen gebruikt. Zulke elektronen zijn minder schadelijk voor biologische en organische materialen. Geelen promoveert op 31 mei.

Promotores: T.H. Oosterkamp, N. de Jonge

Promotor: Prof.dr. J.W.M. Frenken

Triplet superconductivity refers to a condensate of equal-spin Cooper pairs (pairs of electrons with equal spin).

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Promotor: K.E. Schalm, Co-promotor: S.S. Lee

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Promotie

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.